Разбор исследования · Собаки
Кортизол у тяжелобольной собаки: связь с тяжестью есть, прогноз выживания не подтверждён
В исследовании с участием 74 собак исходная концентрация кортизола была связана с оценкой тяжести состояния по APPLE_full. Однако добавление кортизола к модели, учитывавшей группу пациента, не подтвердило улучшения прогноза смертности. Связь с тяжестью состояния нельзя превращать в обещание исхода для конкретной собаки.
Что учитывать: Проспективное наблюдение в одной университетской клинике, без экспериментального назначения вмешательства. Включили 74 собаки вместо запланированных 150; заболевания были разными, а группы небольшими. Пять собак, подвергнутых эвтаназии вскоре после поступления по финансовым причинам, исключены. Действовали ограничения по возрасту, предшествующим препаратам и заболеваниям; SIRS определяли по исследовательскому критерию не менее трёх признаков. Результат относится к кортизолу при поступлении, а не к проверке его изменений в ходе госпитализации. Неподтверждённое улучшение прогноза не доказывает отсутствия любой связи с исходом. Причинный эффект кортизола и индивидуальный прогностический порог работа не устанавливает.
Короткий ответ
Кортизол при поступлении был связан с тяжестью состояния по APPLE_full, однако улучшение прогноза смертности при добавлении кортизола к модели с учётом группы пациента не подтвердилось. Эти результаты нельзя превращать в индивидуальный прогноз.
На чём основано · 1
В проспективное наблюдательное исследование в университетской ветеринарной клинике включили 74 собаки: 30 с синдромом системного воспалительного ответа (SIRS), 25 с острым критическим заболеванием без SIRS и 19 здоровых контрольных собак. Кортизол измеряли при поступлении до лечения; вмешательство исследователями не назначалось.
Граница вывода: Наблюдательный дизайн не устанавливает причинность. Выбранные авторами критерии SIRS и условия интенсивной терапии ограничивают перенос результатов.
Resting Cortisol Concentration as a Predictor of Illness Severity in Critically Ill Dogs With Systemic Inflammatory Response Syndrome.
Точное место: ABSTRACT: Design, Setting, Animals, Interventions
Источник: Andreza Conti‐Patara, Linda G. Martin. Resting Cortisol Concentration as a Predictor of Illness Severity in Critically Ill Dogs With Systemic Inflammatory Response Syndrome. Journal of Veterinary Emergency and Critical Care, 2026. DOI: 10.1111/vec.70167
Условия использования: Creative Commons Attribution (CC BY 4.0): https://creativecommons.org/licenses/by/4.0/ Лицензия источника
Design
Prospective, observational study.
Setting
University teaching hospital.
Animals
Client‐owned dogs were enrolled into three different groups: SIRS (30 dogs), non‐SIRS (25), and healthy controls (19). Dogs with acute critical illness (<48 h) admitted to the ICU were enrolled and classified into SIRS and non‐SIRS groups. Healthy dogs were enrolled as controls. Resting serum cortisol concentrations were measured before treatment. APPLE full and fast scores were calculated at admission, with outcome recorded for each dog.
Interventions
None.Связь с утверждением: подтверждает · полный текст · DOI 10.1111/vec.70167 · опубликован 25 сентября 2026
Resting Cortisol Concentration as a Predictor of Illness Severity in Critically Ill Dogs With Systemic Inflammatory Response Syndrome.
Точное место: 2 Materials and Methods → 2.1 Animals: критерии включения, исключения и запланированная выборка
Источник: Andreza Conti‐Patara, Linda G. Martin. Resting Cortisol Concentration as a Predictor of Illness Severity in Critically Ill Dogs With Systemic Inflammatory Response Syndrome. Journal of Veterinary Emergency and Critical Care, 2026. DOI: 10.1111/vec.70167
Условия использования: Creative Commons Attribution (CC BY 4.0): https://creativecommons.org/licenses/by/4.0/ Лицензия источника
This was an observational, prospective study of dogs over 12 months of age with acute critical illnesses (illness present for <48 h) admitted to a university teaching hospital's small animal ICU from January of 2017 to October of 2018. The study was approved by the Institutional Animal Care and Use Committee, and all dogs were enrolled with written consent from their owners. Sixty client‐owned dogs were eligible for the study and were classified into SIRS and non‐SIRS groups based on the systemic inflammatory response variables of hypothermia (<38.1°C [100.6°F]) or hyperthermia (>39.2°C [102.6°F]), tachycardia (heart rate >120/min), tachypnea (respiratory rate >20/min), leukocytosis (>16 × 10^3 cells/µL), leukopenia (<6 × 10^3 cells/µL), or >3% bands on the WBC count. Based on the definition, patients with two or more criteria and an appropriate underlying condition are considered to have SIRS [12, 13]. To enhance the identification of critically ill patients, the current study considered patients with three or more SIRS variables to have SIRS [14]. Dogs that received exogenous corticosteroids, etomidate, or ketoconazole within the last 4 weeks, and dogs with known malignancies or diseases that involved the pituitary or adrenal glands, were excluded from the study in accordance with the exclusion criteria of a previous study [15]. Five dogs were euthanized shortly after ICU admission due to financial constraints and were excluded from the study, leaving 30 dogs in the SIRS group and 25 dogs in the non‐SIRS group. Additionally, 19 healthy client‐owned dogs that presented to the university teaching hospital's Community Practice service were enrolled as controls. These dogs were presented for elective periodontal treatment, and the relevant data were obtained on the preanesthetic evaluation. The same eligibility criteria were used for the control group as the SIRS and non‐SIRS groups. Dogs were classified as healthy based on history, physical examination, CBC, and serum biochemistry results. A power analysis was conducted before the study, indicating that 150 dogs should be included and distributed equally across the groups. However, due to an insufficient caseload and a specific inclusion criterion, a total of 74 dogs were ultimately enrolled.Связь с утверждением: подтверждает · полный текст · DOI 10.1111/vec.70167 · опубликован 25 сентября 2026
На чём основано · 2
В изученной выборке более высокой на 62,5 нмоль/л концентрации кортизола при поступлении соответствовал более высокий на 1 балл показатель тяжести состояния APPLE_full; 95%-й доверительный интервал оценки составлял 0,6–1,4 балла.
Граница вывода: Это статистическая связь с оценкой тяжести состояния, а не доказательство того, что кортизол вызывает ухудшение. Коэффициент регрессии не является порогом для решения о лечении или прогнозом для отдельной собаки. Наблюдение относится к измерению при поступлении и не описывает изменение показателей одной собаки во времени.
Resting Cortisol Concentration as a Predictor of Illness Severity in Critically Ill Dogs With Systemic Inflammatory Response Syndrome.
Точное место: ABSTRACT: Design, Setting, Animals, Interventions
Источник: Andreza Conti‐Patara, Linda G. Martin. Resting Cortisol Concentration as a Predictor of Illness Severity in Critically Ill Dogs With Systemic Inflammatory Response Syndrome. Journal of Veterinary Emergency and Critical Care, 2026. DOI: 10.1111/vec.70167
Условия использования: Creative Commons Attribution (CC BY 4.0): https://creativecommons.org/licenses/by/4.0/ Лицензия источника
Design
Prospective, observational study.
Setting
University teaching hospital.
Animals
Client‐owned dogs were enrolled into three different groups: SIRS (30 dogs), non‐SIRS (25), and healthy controls (19). Dogs with acute critical illness (<48 h) admitted to the ICU were enrolled and classified into SIRS and non‐SIRS groups. Healthy dogs were enrolled as controls. Resting serum cortisol concentrations were measured before treatment. APPLE full and fast scores were calculated at admission, with outcome recorded for each dog.
Interventions
None.Связь с утверждением: подтверждает · полный текст · DOI 10.1111/vec.70167 · опубликован 25 сентября 2026
Resting Cortisol Concentration as a Predictor of Illness Severity in Critically Ill Dogs With Systemic Inflammatory Response Syndrome.
Точное место: 3 Results: абзац непосредственно перед Figure 2, связь кортизола с APPLE_full
Источник: Andreza Conti‐Patara, Linda G. Martin. Resting Cortisol Concentration as a Predictor of Illness Severity in Critically Ill Dogs With Systemic Inflammatory Response Syndrome. Journal of Veterinary Emergency and Critical Care, 2026. DOI: 10.1111/vec.70167
Условия использования: Creative Commons Attribution (CC BY 4.0): https://creativecommons.org/licenses/by/4.0/ Лицензия источника
The APPLE_full scores increased by 1 (95% confidence interval [CI]: 0.6–1.4) for every increase of 62.5 nmol/L (2.2 µg/dL) in resting serum cortisol concentration (Figure 2).Связь с утверждением: подтверждает · полный текст · DOI 10.1111/vec.70167 · опубликован 25 сентября 2026
Resting Cortisol Concentration as a Predictor of Illness Severity in Critically Ill Dogs With Systemic Inflammatory Response Syndrome.
Точное место: 3 Results: абзац после Figure 1, предложение о составе регрессионной модели APPLE_full перед Table 1
Источник: Andreza Conti‐Patara, Linda G. Martin. Resting Cortisol Concentration as a Predictor of Illness Severity in Critically Ill Dogs With Systemic Inflammatory Response Syndrome. Journal of Veterinary Emergency and Critical Care, 2026. DOI: 10.1111/vec.70167
Условия использования: Creative Commons Attribution (CC BY 4.0): https://creativecommons.org/licenses/by/4.0/ Лицензия источника
A linear regression model was fit to relate the APPLE_full score to the three groups and resting serum cortisol concentration at the time of hospital admission (Table 1).Связь с утверждением: подтверждает · полный текст · DOI 10.1111/vec.70167 · опубликован 25 сентября 2026
На чём основано · 3
В этой выборке не получили статистических свидетельств того, что добавление кортизола при поступлении улучшает прогноз смертности по сравнению с моделью, учитывающей только группу (p = 0,33). Для добавления APPLE_full авторы сообщили умеренные статистические свидетельства улучшения прогноза (p = 0,03).
Граница вывода: Отсутствие статистических свидетельств улучшения не доказывает отсутствие прогностической связи в любой популяции. Результат относится к измерению при поступлении, выбранным группам и исходу до выписки; он не задаёт индивидуальную вероятность выживания.
Resting Cortisol Concentration as a Predictor of Illness Severity in Critically Ill Dogs With Systemic Inflammatory Response Syndrome.
Точное место: 2 Materials and Methods → 2.5 Outcome: определение исхода и лечение
Источник: Andreza Conti‐Patara, Linda G. Martin. Resting Cortisol Concentration as a Predictor of Illness Severity in Critically Ill Dogs With Systemic Inflammatory Response Syndrome. Journal of Veterinary Emergency and Critical Care, 2026. DOI: 10.1111/vec.70167
Условия использования: Creative Commons Attribution (CC BY 4.0): https://creativecommons.org/licenses/by/4.0/ Лицензия источника
Outcome was recorded as survival to hospital discharge or nonsurvival. All dogs that did not survive died of natural causes; dogs that were euthanized were excluded from the study. The treatment of each dog enrolled in the study was determined by its primary clinician.Связь с утверждением: подтверждает · полный текст · DOI 10.1111/vec.70167 · опубликован 25 сентября 2026
Resting Cortisol Concentration as a Predictor of Illness Severity in Critically Ill Dogs With Systemic Inflammatory Response Syndrome.
Точное место: 3 Results: абзац после Figure 1, число умерших и сравнение моделей прогноза смертности
Источник: Andreza Conti‐Patara, Linda G. Martin. Resting Cortisol Concentration as a Predictor of Illness Severity in Critically Ill Dogs With Systemic Inflammatory Response Syndrome. Journal of Veterinary Emergency and Critical Care, 2026. DOI: 10.1111/vec.70167
Условия использования: Creative Commons Attribution (CC BY 4.0): https://creativecommons.org/licenses/by/4.0/ Лицензия источника
Twelve of 30 dogs in the SIRS group and four of 25 dogs in the non‐SIRS group died. Resting serum cortisol concentrations tended to be higher in nonsurvivors (452.50 nmol/L; range: 162–1380 nmol/L [16.4 µg/dL; range: 5.8–50 µg/dL]) compared with survivors in the SIRS group (274.5 nmol/L; range: 73–1222 nmol/L [9.9 µg/dL; range: 2.6–44.2 µg/dL]); however, they were not significantly different (p = 0.1). In the non‐SIRS group, resting serum cortisol concentrations were the same in nonsurvivors (208.5 nmol/L; range: 121–494 [7.5 µg/dL, range: 4.3–17.9 µg/dL]) as in survivors (219 nmol/L; range: 74–861 [7.9 µg/dL; range: 2.6–31.2 µg/dL]; p = 0.9). The likelihood ratio tests were performed to assess the significance of the predictive outcomes of APPLE_full and APPLE_fast scores and resting serum cortisol concentration and to compare them with the model with only the group. There was no evidence that including APPLE_fast (p = 0.14) or resting serum cortisol concentration (p = 0.33) improves outcome prediction compared with a model with group factor alone. There was moderate evidence that including APPLE_full scores (p = 0.03) improves predictions of mortality.Связь с утверждением: подтверждает · полный текст · DOI 10.1111/vec.70167 · опубликован 25 сентября 2026
На чём основано · 4
До начала исследования расчёт предусматривал 150 собак, но включили 74. Пять собак, эвтаназированных вскоре после поступления по финансовым причинам, исключили. Авторы также отмечают неоднородность заболеваний, малые группы и отсутствие оценки кортизола в разные моменты госпитализации.
Граница вывода: Малые неоднородные группы ограничивают статистическую мощность и перенос результатов. Исключение эвтаназированных собак ограничивает применимость описанного исхода ко всем поступающим пациентам. Причинный эффект кортизола и преимущества изменения лечения не проверялись.
Resting Cortisol Concentration as a Predictor of Illness Severity in Critically Ill Dogs With Systemic Inflammatory Response Syndrome.
Точное место: ABSTRACT: Design, Setting, Animals, Interventions
Источник: Andreza Conti‐Patara, Linda G. Martin. Resting Cortisol Concentration as a Predictor of Illness Severity in Critically Ill Dogs With Systemic Inflammatory Response Syndrome. Journal of Veterinary Emergency and Critical Care, 2026. DOI: 10.1111/vec.70167
Условия использования: Creative Commons Attribution (CC BY 4.0): https://creativecommons.org/licenses/by/4.0/ Лицензия источника
Design
Prospective, observational study.
Setting
University teaching hospital.
Animals
Client‐owned dogs were enrolled into three different groups: SIRS (30 dogs), non‐SIRS (25), and healthy controls (19). Dogs with acute critical illness (<48 h) admitted to the ICU were enrolled and classified into SIRS and non‐SIRS groups. Healthy dogs were enrolled as controls. Resting serum cortisol concentrations were measured before treatment. APPLE full and fast scores were calculated at admission, with outcome recorded for each dog.
Interventions
None.Связь с утверждением: подтверждает · полный текст · DOI 10.1111/vec.70167 · опубликован 25 сентября 2026
Resting Cortisol Concentration as a Predictor of Illness Severity in Critically Ill Dogs With Systemic Inflammatory Response Syndrome.
Точное место: 2 Materials and Methods → 2.1 Animals: критерии включения, исключения и запланированная выборка
Источник: Andreza Conti‐Patara, Linda G. Martin. Resting Cortisol Concentration as a Predictor of Illness Severity in Critically Ill Dogs With Systemic Inflammatory Response Syndrome. Journal of Veterinary Emergency and Critical Care, 2026. DOI: 10.1111/vec.70167
Условия использования: Creative Commons Attribution (CC BY 4.0): https://creativecommons.org/licenses/by/4.0/ Лицензия источника
This was an observational, prospective study of dogs over 12 months of age with acute critical illnesses (illness present for <48 h) admitted to a university teaching hospital's small animal ICU from January of 2017 to October of 2018. The study was approved by the Institutional Animal Care and Use Committee, and all dogs were enrolled with written consent from their owners. Sixty client‐owned dogs were eligible for the study and were classified into SIRS and non‐SIRS groups based on the systemic inflammatory response variables of hypothermia (<38.1°C [100.6°F]) or hyperthermia (>39.2°C [102.6°F]), tachycardia (heart rate >120/min), tachypnea (respiratory rate >20/min), leukocytosis (>16 × 10^3 cells/µL), leukopenia (<6 × 10^3 cells/µL), or >3% bands on the WBC count. Based on the definition, patients with two or more criteria and an appropriate underlying condition are considered to have SIRS [12, 13]. To enhance the identification of critically ill patients, the current study considered patients with three or more SIRS variables to have SIRS [14]. Dogs that received exogenous corticosteroids, etomidate, or ketoconazole within the last 4 weeks, and dogs with known malignancies or diseases that involved the pituitary or adrenal glands, were excluded from the study in accordance with the exclusion criteria of a previous study [15]. Five dogs were euthanized shortly after ICU admission due to financial constraints and were excluded from the study, leaving 30 dogs in the SIRS group and 25 dogs in the non‐SIRS group. Additionally, 19 healthy client‐owned dogs that presented to the university teaching hospital's Community Practice service were enrolled as controls. These dogs were presented for elective periodontal treatment, and the relevant data were obtained on the preanesthetic evaluation. The same eligibility criteria were used for the control group as the SIRS and non‐SIRS groups. Dogs were classified as healthy based on history, physical examination, CBC, and serum biochemistry results. A power analysis was conducted before the study, indicating that 150 dogs should be included and distributed equally across the groups. However, due to an insufficient caseload and a specific inclusion criterion, a total of 74 dogs were ultimately enrolled.Связь с утверждением: подтверждает · полный текст · DOI 10.1111/vec.70167 · опубликован 25 сентября 2026
Resting Cortisol Concentration as a Predictor of Illness Severity in Critically Ill Dogs With Systemic Inflammatory Response Syndrome.
Точное место: 4 Discussion: абзац «The current study also showed», неоднородность заболеваний, малая выборка и отсутствие повторных измерений
Источник: Andreza Conti‐Patara, Linda G. Martin. Resting Cortisol Concentration as a Predictor of Illness Severity in Critically Ill Dogs With Systemic Inflammatory Response Syndrome. Journal of Veterinary Emergency and Critical Care, 2026. DOI: 10.1111/vec.70167
Условия использования: Creative Commons Attribution (CC BY 4.0): https://creativecommons.org/licenses/by/4.0/ Лицензия источника
The current study also showed that nonsurvivors often presented with numerically higher resting serum cortisol concentrations than survivors. However, no statistical difference was found between the two groups, which agrees with previous studies [7, 8, 18]. Resting serum cortisol concentrations did not predict mortality, likely due to the variability of disease processes and the small number of cases enrolled in each group. Serum cortisol concentration was a good predictor of outcome in dogs with parvoviral enteritis when resting serum cortisol was measured at 24 and 48 h of hospitalization [8] and at 72 h of hospitalization [7]. The current study did not evaluate resting serum cortisol concentrations at different time points; however, it may indicate that resting serum cortisol concentrations measured at times other than admission to the hospital may be more helpful in determining patient outcomes.Связь с утверждением: подтверждает · полный текст · DOI 10.1111/vec.70167 · опубликован 25 сентября 2026
Как устроено исследование
Это проспективное наблюдение в университетской ветеринарной клинике. Набор проходил с января 2017 года по октябрь 2018 года. Включали собак старше 12 месяцев с острым критическим заболеванием продолжительностью менее 48 часов. Кортизол измеряли до лечения при поступлении; тогда же рассчитывали шкалы APPLE. Экспериментального вмешательства не было. Исходом считали выживание до выписки либо смерть.
На чём основано · 1
В проспективное наблюдательное исследование в университетской ветеринарной клинике включили 74 собаки: 30 с синдромом системного воспалительного ответа (SIRS), 25 с острым критическим заболеванием без SIRS и 19 здоровых контрольных собак. Кортизол измеряли при поступлении до лечения; вмешательство исследователями не назначалось.
Граница вывода: Наблюдательный дизайн не устанавливает причинность. Выбранные авторами критерии SIRS и условия интенсивной терапии ограничивают перенос результатов.
Resting Cortisol Concentration as a Predictor of Illness Severity in Critically Ill Dogs With Systemic Inflammatory Response Syndrome.
Точное место: ABSTRACT: Design, Setting, Animals, Interventions
Источник: Andreza Conti‐Patara, Linda G. Martin. Resting Cortisol Concentration as a Predictor of Illness Severity in Critically Ill Dogs With Systemic Inflammatory Response Syndrome. Journal of Veterinary Emergency and Critical Care, 2026. DOI: 10.1111/vec.70167
Условия использования: Creative Commons Attribution (CC BY 4.0): https://creativecommons.org/licenses/by/4.0/ Лицензия источника
Design
Prospective, observational study.
Setting
University teaching hospital.
Animals
Client‐owned dogs were enrolled into three different groups: SIRS (30 dogs), non‐SIRS (25), and healthy controls (19). Dogs with acute critical illness (<48 h) admitted to the ICU were enrolled and classified into SIRS and non‐SIRS groups. Healthy dogs were enrolled as controls. Resting serum cortisol concentrations were measured before treatment. APPLE full and fast scores were calculated at admission, with outcome recorded for each dog.
Interventions
None.Связь с утверждением: подтверждает · полный текст · DOI 10.1111/vec.70167 · опубликован 25 сентября 2026
Resting Cortisol Concentration as a Predictor of Illness Severity in Critically Ill Dogs With Systemic Inflammatory Response Syndrome.
Точное место: 2 Materials and Methods → 2.1 Animals: критерии включения, исключения и запланированная выборка
Источник: Andreza Conti‐Patara, Linda G. Martin. Resting Cortisol Concentration as a Predictor of Illness Severity in Critically Ill Dogs With Systemic Inflammatory Response Syndrome. Journal of Veterinary Emergency and Critical Care, 2026. DOI: 10.1111/vec.70167
Условия использования: Creative Commons Attribution (CC BY 4.0): https://creativecommons.org/licenses/by/4.0/ Лицензия источника
This was an observational, prospective study of dogs over 12 months of age with acute critical illnesses (illness present for <48 h) admitted to a university teaching hospital's small animal ICU from January of 2017 to October of 2018. The study was approved by the Institutional Animal Care and Use Committee, and all dogs were enrolled with written consent from their owners. Sixty client‐owned dogs were eligible for the study and were classified into SIRS and non‐SIRS groups based on the systemic inflammatory response variables of hypothermia (<38.1°C [100.6°F]) or hyperthermia (>39.2°C [102.6°F]), tachycardia (heart rate >120/min), tachypnea (respiratory rate >20/min), leukocytosis (>16 × 10^3 cells/µL), leukopenia (<6 × 10^3 cells/µL), or >3% bands on the WBC count. Based on the definition, patients with two or more criteria and an appropriate underlying condition are considered to have SIRS [12, 13]. To enhance the identification of critically ill patients, the current study considered patients with three or more SIRS variables to have SIRS [14]. Dogs that received exogenous corticosteroids, etomidate, or ketoconazole within the last 4 weeks, and dogs with known malignancies or diseases that involved the pituitary or adrenal glands, were excluded from the study in accordance with the exclusion criteria of a previous study [15]. Five dogs were euthanized shortly after ICU admission due to financial constraints and were excluded from the study, leaving 30 dogs in the SIRS group and 25 dogs in the non‐SIRS group. Additionally, 19 healthy client‐owned dogs that presented to the university teaching hospital's Community Practice service were enrolled as controls. These dogs were presented for elective periodontal treatment, and the relevant data were obtained on the preanesthetic evaluation. The same eligibility criteria were used for the control group as the SIRS and non‐SIRS groups. Dogs were classified as healthy based on history, physical examination, CBC, and serum biochemistry results. A power analysis was conducted before the study, indicating that 150 dogs should be included and distributed equally across the groups. However, due to an insufficient caseload and a specific inclusion criterion, a total of 74 dogs were ultimately enrolled.Связь с утверждением: подтверждает · полный текст · DOI 10.1111/vec.70167 · опубликован 25 сентября 2026
На чём основано · 2
В этой выборке не получили статистических свидетельств того, что добавление кортизола при поступлении улучшает прогноз смертности по сравнению с моделью, учитывающей только группу (p = 0,33). Для добавления APPLE_full авторы сообщили умеренные статистические свидетельства улучшения прогноза (p = 0,03).
Граница вывода: Отсутствие статистических свидетельств улучшения не доказывает отсутствие прогностической связи в любой популяции. Результат относится к измерению при поступлении, выбранным группам и исходу до выписки; он не задаёт индивидуальную вероятность выживания.
Resting Cortisol Concentration as a Predictor of Illness Severity in Critically Ill Dogs With Systemic Inflammatory Response Syndrome.
Точное место: 2 Materials and Methods → 2.5 Outcome: определение исхода и лечение
Источник: Andreza Conti‐Patara, Linda G. Martin. Resting Cortisol Concentration as a Predictor of Illness Severity in Critically Ill Dogs With Systemic Inflammatory Response Syndrome. Journal of Veterinary Emergency and Critical Care, 2026. DOI: 10.1111/vec.70167
Условия использования: Creative Commons Attribution (CC BY 4.0): https://creativecommons.org/licenses/by/4.0/ Лицензия источника
Outcome was recorded as survival to hospital discharge or nonsurvival. All dogs that did not survive died of natural causes; dogs that were euthanized were excluded from the study. The treatment of each dog enrolled in the study was determined by its primary clinician.Связь с утверждением: подтверждает · полный текст · DOI 10.1111/vec.70167 · опубликован 25 сентября 2026
Resting Cortisol Concentration as a Predictor of Illness Severity in Critically Ill Dogs With Systemic Inflammatory Response Syndrome.
Точное место: 3 Results: абзац после Figure 1, число умерших и сравнение моделей прогноза смертности
Источник: Andreza Conti‐Patara, Linda G. Martin. Resting Cortisol Concentration as a Predictor of Illness Severity in Critically Ill Dogs With Systemic Inflammatory Response Syndrome. Journal of Veterinary Emergency and Critical Care, 2026. DOI: 10.1111/vec.70167
Условия использования: Creative Commons Attribution (CC BY 4.0): https://creativecommons.org/licenses/by/4.0/ Лицензия источника
Twelve of 30 dogs in the SIRS group and four of 25 dogs in the non‐SIRS group died. Resting serum cortisol concentrations tended to be higher in nonsurvivors (452.50 nmol/L; range: 162–1380 nmol/L [16.4 µg/dL; range: 5.8–50 µg/dL]) compared with survivors in the SIRS group (274.5 nmol/L; range: 73–1222 nmol/L [9.9 µg/dL; range: 2.6–44.2 µg/dL]); however, they were not significantly different (p = 0.1). In the non‐SIRS group, resting serum cortisol concentrations were the same in nonsurvivors (208.5 nmol/L; range: 121–494 [7.5 µg/dL, range: 4.3–17.9 µg/dL]) as in survivors (219 nmol/L; range: 74–861 [7.9 µg/dL; range: 2.6–31.2 µg/dL]; p = 0.9). The likelihood ratio tests were performed to assess the significance of the predictive outcomes of APPLE_full and APPLE_fast scores and resting serum cortisol concentration and to compare them with the model with only the group. There was no evidence that including APPLE_fast (p = 0.14) or resting serum cortisol concentration (p = 0.33) improves outcome prediction compared with a model with group factor alone. There was moderate evidence that including APPLE_full scores (p = 0.03) improves predictions of mortality.Связь с утверждением: подтверждает · полный текст · DOI 10.1111/vec.70167 · опубликован 25 сентября 2026
| Группа | Число собак | Что означает группа |
|---|---|---|
| С синдромом системной воспалительной реакции (SIRS) | 30 | Не менее трёх соответствующих признаков по критерию исследования |
| Другие собаки с острым критическим заболеванием | 25 | Не отвечали принятому в исследовании критерию SIRS |
| Здоровая группа сравнения | 19 | Здоровые собаки, обследованные перед плановым стоматологическим вмешательством |
На чём основано
В проспективное наблюдательное исследование в университетской ветеринарной клинике включили 74 собаки: 30 с синдромом системного воспалительного ответа (SIRS), 25 с острым критическим заболеванием без SIRS и 19 здоровых контрольных собак. Кортизол измеряли при поступлении до лечения; вмешательство исследователями не назначалось.
Граница вывода: Наблюдательный дизайн не устанавливает причинность. Выбранные авторами критерии SIRS и условия интенсивной терапии ограничивают перенос результатов.
Resting Cortisol Concentration as a Predictor of Illness Severity in Critically Ill Dogs With Systemic Inflammatory Response Syndrome.
Точное место: ABSTRACT: Design, Setting, Animals, Interventions
Источник: Andreza Conti‐Patara, Linda G. Martin. Resting Cortisol Concentration as a Predictor of Illness Severity in Critically Ill Dogs With Systemic Inflammatory Response Syndrome. Journal of Veterinary Emergency and Critical Care, 2026. DOI: 10.1111/vec.70167
Условия использования: Creative Commons Attribution (CC BY 4.0): https://creativecommons.org/licenses/by/4.0/ Лицензия источника
Design
Prospective, observational study.
Setting
University teaching hospital.
Animals
Client‐owned dogs were enrolled into three different groups: SIRS (30 dogs), non‐SIRS (25), and healthy controls (19). Dogs with acute critical illness (<48 h) admitted to the ICU were enrolled and classified into SIRS and non‐SIRS groups. Healthy dogs were enrolled as controls. Resting serum cortisol concentrations were measured before treatment. APPLE full and fast scores were calculated at admission, with outcome recorded for each dog.
Interventions
None.Связь с утверждением: подтверждает · полный текст · DOI 10.1111/vec.70167 · опубликован 25 сентября 2026
Resting Cortisol Concentration as a Predictor of Illness Severity in Critically Ill Dogs With Systemic Inflammatory Response Syndrome.
Точное место: 2 Materials and Methods → 2.1 Animals: критерии включения, исключения и запланированная выборка
Источник: Andreza Conti‐Patara, Linda G. Martin. Resting Cortisol Concentration as a Predictor of Illness Severity in Critically Ill Dogs With Systemic Inflammatory Response Syndrome. Journal of Veterinary Emergency and Critical Care, 2026. DOI: 10.1111/vec.70167
Условия использования: Creative Commons Attribution (CC BY 4.0): https://creativecommons.org/licenses/by/4.0/ Лицензия источника
This was an observational, prospective study of dogs over 12 months of age with acute critical illnesses (illness present for <48 h) admitted to a university teaching hospital's small animal ICU from January of 2017 to October of 2018. The study was approved by the Institutional Animal Care and Use Committee, and all dogs were enrolled with written consent from their owners. Sixty client‐owned dogs were eligible for the study and were classified into SIRS and non‐SIRS groups based on the systemic inflammatory response variables of hypothermia (<38.1°C [100.6°F]) or hyperthermia (>39.2°C [102.6°F]), tachycardia (heart rate >120/min), tachypnea (respiratory rate >20/min), leukocytosis (>16 × 10^3 cells/µL), leukopenia (<6 × 10^3 cells/µL), or >3% bands on the WBC count. Based on the definition, patients with two or more criteria and an appropriate underlying condition are considered to have SIRS [12, 13]. To enhance the identification of critically ill patients, the current study considered patients with three or more SIRS variables to have SIRS [14]. Dogs that received exogenous corticosteroids, etomidate, or ketoconazole within the last 4 weeks, and dogs with known malignancies or diseases that involved the pituitary or adrenal glands, were excluded from the study in accordance with the exclusion criteria of a previous study [15]. Five dogs were euthanized shortly after ICU admission due to financial constraints and were excluded from the study, leaving 30 dogs in the SIRS group and 25 dogs in the non‐SIRS group. Additionally, 19 healthy client‐owned dogs that presented to the university teaching hospital's Community Practice service were enrolled as controls. These dogs were presented for elective periodontal treatment, and the relevant data were obtained on the preanesthetic evaluation. The same eligibility criteria were used for the control group as the SIRS and non‐SIRS groups. Dogs were classified as healthy based on history, physical examination, CBC, and serum biochemistry results. A power analysis was conducted before the study, indicating that 150 dogs should be included and distributed equally across the groups. However, due to an insufficient caseload and a specific inclusion criterion, a total of 74 dogs were ultimately enrolled.Связь с утверждением: подтверждает · полный текст · DOI 10.1111/vec.70167 · опубликован 25 сентября 2026
Группа без SIRS определена по правилам именно этой работы. Её название нельзя читать как доказательство отсутствия воспаления у всех включённых собак.
На чём основано
В проспективное наблюдательное исследование в университетской ветеринарной клинике включили 74 собаки: 30 с синдромом системного воспалительного ответа (SIRS), 25 с острым критическим заболеванием без SIRS и 19 здоровых контрольных собак. Кортизол измеряли при поступлении до лечения; вмешательство исследователями не назначалось.
Граница вывода: Наблюдательный дизайн не устанавливает причинность. Выбранные авторами критерии SIRS и условия интенсивной терапии ограничивают перенос результатов.
Resting Cortisol Concentration as a Predictor of Illness Severity in Critically Ill Dogs With Systemic Inflammatory Response Syndrome.
Точное место: ABSTRACT: Design, Setting, Animals, Interventions
Источник: Andreza Conti‐Patara, Linda G. Martin. Resting Cortisol Concentration as a Predictor of Illness Severity in Critically Ill Dogs With Systemic Inflammatory Response Syndrome. Journal of Veterinary Emergency and Critical Care, 2026. DOI: 10.1111/vec.70167
Условия использования: Creative Commons Attribution (CC BY 4.0): https://creativecommons.org/licenses/by/4.0/ Лицензия источника
Design
Prospective, observational study.
Setting
University teaching hospital.
Animals
Client‐owned dogs were enrolled into three different groups: SIRS (30 dogs), non‐SIRS (25), and healthy controls (19). Dogs with acute critical illness (<48 h) admitted to the ICU were enrolled and classified into SIRS and non‐SIRS groups. Healthy dogs were enrolled as controls. Resting serum cortisol concentrations were measured before treatment. APPLE full and fast scores were calculated at admission, with outcome recorded for each dog.
Interventions
None.Связь с утверждением: подтверждает · полный текст · DOI 10.1111/vec.70167 · опубликован 25 сентября 2026
Resting Cortisol Concentration as a Predictor of Illness Severity in Critically Ill Dogs With Systemic Inflammatory Response Syndrome.
Точное место: 2 Materials and Methods → 2.1 Animals: критерии включения, исключения и запланированная выборка
Источник: Andreza Conti‐Patara, Linda G. Martin. Resting Cortisol Concentration as a Predictor of Illness Severity in Critically Ill Dogs With Systemic Inflammatory Response Syndrome. Journal of Veterinary Emergency and Critical Care, 2026. DOI: 10.1111/vec.70167
Условия использования: Creative Commons Attribution (CC BY 4.0): https://creativecommons.org/licenses/by/4.0/ Лицензия источника
This was an observational, prospective study of dogs over 12 months of age with acute critical illnesses (illness present for <48 h) admitted to a university teaching hospital's small animal ICU from January of 2017 to October of 2018. The study was approved by the Institutional Animal Care and Use Committee, and all dogs were enrolled with written consent from their owners. Sixty client‐owned dogs were eligible for the study and were classified into SIRS and non‐SIRS groups based on the systemic inflammatory response variables of hypothermia (<38.1°C [100.6°F]) or hyperthermia (>39.2°C [102.6°F]), tachycardia (heart rate >120/min), tachypnea (respiratory rate >20/min), leukocytosis (>16 × 10^3 cells/µL), leukopenia (<6 × 10^3 cells/µL), or >3% bands on the WBC count. Based on the definition, patients with two or more criteria and an appropriate underlying condition are considered to have SIRS [12, 13]. To enhance the identification of critically ill patients, the current study considered patients with three or more SIRS variables to have SIRS [14]. Dogs that received exogenous corticosteroids, etomidate, or ketoconazole within the last 4 weeks, and dogs with known malignancies or diseases that involved the pituitary or adrenal glands, were excluded from the study in accordance with the exclusion criteria of a previous study [15]. Five dogs were euthanized shortly after ICU admission due to financial constraints and were excluded from the study, leaving 30 dogs in the SIRS group and 25 dogs in the non‐SIRS group. Additionally, 19 healthy client‐owned dogs that presented to the university teaching hospital's Community Practice service were enrolled as controls. These dogs were presented for elective periodontal treatment, and the relevant data were obtained on the preanesthetic evaluation. The same eligibility criteria were used for the control group as the SIRS and non‐SIRS groups. Dogs were classified as healthy based on history, physical examination, CBC, and serum biochemistry results. A power analysis was conducted before the study, indicating that 150 dogs should be included and distributed equally across the groups. However, due to an insufficient caseload and a specific inclusion criterion, a total of 74 dogs were ultimately enrolled.Связь с утверждением: подтверждает · полный текст · DOI 10.1111/vec.70167 · опубликован 25 сентября 2026
Тяжесть состояния и прогноз исхода — разные проверки
| Вопрос | Результат исследования | Что из него следует |
|---|---|---|
| Связан ли кортизол с APPLE_full? | Увеличению кортизола на 62,5 нмоль/л соответствовал рост APPLE_full на 1 балл; 95%-й доверительный интервал — 0,6–1,4 балла | Обнаружена статистическая связь; причинное влияние кортизола не установлено |
| Улучшал ли кортизол прогноз смертности? | Добавление к модели с учётом группы пациента не подтвердило улучшения прогноза: p = 0,33 | Прогностическая добавочная ценность в этой выборке не подтверждена |
| Что показала полная шкала APPLE? | Для добавления APPLE_full авторы получили умеренные статистические свидетельства улучшения прогноза: p = 0,03 | Это результат модели в изученной выборке, а не индивидуальная гарантия |
На чём основано · 1
В изученной выборке более высокой на 62,5 нмоль/л концентрации кортизола при поступлении соответствовал более высокий на 1 балл показатель тяжести состояния APPLE_full; 95%-й доверительный интервал оценки составлял 0,6–1,4 балла.
Граница вывода: Это статистическая связь с оценкой тяжести состояния, а не доказательство того, что кортизол вызывает ухудшение. Коэффициент регрессии не является порогом для решения о лечении или прогнозом для отдельной собаки. Наблюдение относится к измерению при поступлении и не описывает изменение показателей одной собаки во времени.
Resting Cortisol Concentration as a Predictor of Illness Severity in Critically Ill Dogs With Systemic Inflammatory Response Syndrome.
Точное место: ABSTRACT: Design, Setting, Animals, Interventions
Источник: Andreza Conti‐Patara, Linda G. Martin. Resting Cortisol Concentration as a Predictor of Illness Severity in Critically Ill Dogs With Systemic Inflammatory Response Syndrome. Journal of Veterinary Emergency and Critical Care, 2026. DOI: 10.1111/vec.70167
Условия использования: Creative Commons Attribution (CC BY 4.0): https://creativecommons.org/licenses/by/4.0/ Лицензия источника
Design
Prospective, observational study.
Setting
University teaching hospital.
Animals
Client‐owned dogs were enrolled into three different groups: SIRS (30 dogs), non‐SIRS (25), and healthy controls (19). Dogs with acute critical illness (<48 h) admitted to the ICU were enrolled and classified into SIRS and non‐SIRS groups. Healthy dogs were enrolled as controls. Resting serum cortisol concentrations were measured before treatment. APPLE full and fast scores were calculated at admission, with outcome recorded for each dog.
Interventions
None.Связь с утверждением: подтверждает · полный текст · DOI 10.1111/vec.70167 · опубликован 25 сентября 2026
Resting Cortisol Concentration as a Predictor of Illness Severity in Critically Ill Dogs With Systemic Inflammatory Response Syndrome.
Точное место: 3 Results: абзац непосредственно перед Figure 2, связь кортизола с APPLE_full
Источник: Andreza Conti‐Patara, Linda G. Martin. Resting Cortisol Concentration as a Predictor of Illness Severity in Critically Ill Dogs With Systemic Inflammatory Response Syndrome. Journal of Veterinary Emergency and Critical Care, 2026. DOI: 10.1111/vec.70167
Условия использования: Creative Commons Attribution (CC BY 4.0): https://creativecommons.org/licenses/by/4.0/ Лицензия источника
The APPLE_full scores increased by 1 (95% confidence interval [CI]: 0.6–1.4) for every increase of 62.5 nmol/L (2.2 µg/dL) in resting serum cortisol concentration (Figure 2).Связь с утверждением: подтверждает · полный текст · DOI 10.1111/vec.70167 · опубликован 25 сентября 2026
Resting Cortisol Concentration as a Predictor of Illness Severity in Critically Ill Dogs With Systemic Inflammatory Response Syndrome.
Точное место: 3 Results: абзац после Figure 1, предложение о составе регрессионной модели APPLE_full перед Table 1
Источник: Andreza Conti‐Patara, Linda G. Martin. Resting Cortisol Concentration as a Predictor of Illness Severity in Critically Ill Dogs With Systemic Inflammatory Response Syndrome. Journal of Veterinary Emergency and Critical Care, 2026. DOI: 10.1111/vec.70167
Условия использования: Creative Commons Attribution (CC BY 4.0): https://creativecommons.org/licenses/by/4.0/ Лицензия источника
A linear regression model was fit to relate the APPLE_full score to the three groups and resting serum cortisol concentration at the time of hospital admission (Table 1).Связь с утверждением: подтверждает · полный текст · DOI 10.1111/vec.70167 · опубликован 25 сентября 2026
На чём основано · 2
В этой выборке не получили статистических свидетельств того, что добавление кортизола при поступлении улучшает прогноз смертности по сравнению с моделью, учитывающей только группу (p = 0,33). Для добавления APPLE_full авторы сообщили умеренные статистические свидетельства улучшения прогноза (p = 0,03).
Граница вывода: Отсутствие статистических свидетельств улучшения не доказывает отсутствие прогностической связи в любой популяции. Результат относится к измерению при поступлении, выбранным группам и исходу до выписки; он не задаёт индивидуальную вероятность выживания.
Resting Cortisol Concentration as a Predictor of Illness Severity in Critically Ill Dogs With Systemic Inflammatory Response Syndrome.
Точное место: 2 Materials and Methods → 2.5 Outcome: определение исхода и лечение
Источник: Andreza Conti‐Patara, Linda G. Martin. Resting Cortisol Concentration as a Predictor of Illness Severity in Critically Ill Dogs With Systemic Inflammatory Response Syndrome. Journal of Veterinary Emergency and Critical Care, 2026. DOI: 10.1111/vec.70167
Условия использования: Creative Commons Attribution (CC BY 4.0): https://creativecommons.org/licenses/by/4.0/ Лицензия источника
Outcome was recorded as survival to hospital discharge or nonsurvival. All dogs that did not survive died of natural causes; dogs that were euthanized were excluded from the study. The treatment of each dog enrolled in the study was determined by its primary clinician.Связь с утверждением: подтверждает · полный текст · DOI 10.1111/vec.70167 · опубликован 25 сентября 2026
Resting Cortisol Concentration as a Predictor of Illness Severity in Critically Ill Dogs With Systemic Inflammatory Response Syndrome.
Точное место: 3 Results: абзац после Figure 1, число умерших и сравнение моделей прогноза смертности
Источник: Andreza Conti‐Patara, Linda G. Martin. Resting Cortisol Concentration as a Predictor of Illness Severity in Critically Ill Dogs With Systemic Inflammatory Response Syndrome. Journal of Veterinary Emergency and Critical Care, 2026. DOI: 10.1111/vec.70167
Условия использования: Creative Commons Attribution (CC BY 4.0): https://creativecommons.org/licenses/by/4.0/ Лицензия источника
Twelve of 30 dogs in the SIRS group and four of 25 dogs in the non‐SIRS group died. Resting serum cortisol concentrations tended to be higher in nonsurvivors (452.50 nmol/L; range: 162–1380 nmol/L [16.4 µg/dL; range: 5.8–50 µg/dL]) compared with survivors in the SIRS group (274.5 nmol/L; range: 73–1222 nmol/L [9.9 µg/dL; range: 2.6–44.2 µg/dL]); however, they were not significantly different (p = 0.1). In the non‐SIRS group, resting serum cortisol concentrations were the same in nonsurvivors (208.5 nmol/L; range: 121–494 [7.5 µg/dL, range: 4.3–17.9 µg/dL]) as in survivors (219 nmol/L; range: 74–861 [7.9 µg/dL; range: 2.6–31.2 µg/dL]; p = 0.9). The likelihood ratio tests were performed to assess the significance of the predictive outcomes of APPLE_full and APPLE_fast scores and resting serum cortisol concentration and to compare them with the model with only the group. There was no evidence that including APPLE_fast (p = 0.14) or resting serum cortisol concentration (p = 0.33) improves outcome prediction compared with a model with group factor alone. There was moderate evidence that including APPLE_full scores (p = 0.03) improves predictions of mortality.Связь с утверждением: подтверждает · полный текст · DOI 10.1111/vec.70167 · опубликован 25 сентября 2026
На чём основано · 3
До начала исследования расчёт предусматривал 150 собак, но включили 74. Пять собак, эвтаназированных вскоре после поступления по финансовым причинам, исключили. Авторы также отмечают неоднородность заболеваний, малые группы и отсутствие оценки кортизола в разные моменты госпитализации.
Граница вывода: Малые неоднородные группы ограничивают статистическую мощность и перенос результатов. Исключение эвтаназированных собак ограничивает применимость описанного исхода ко всем поступающим пациентам. Причинный эффект кортизола и преимущества изменения лечения не проверялись.
Resting Cortisol Concentration as a Predictor of Illness Severity in Critically Ill Dogs With Systemic Inflammatory Response Syndrome.
Точное место: ABSTRACT: Design, Setting, Animals, Interventions
Источник: Andreza Conti‐Patara, Linda G. Martin. Resting Cortisol Concentration as a Predictor of Illness Severity in Critically Ill Dogs With Systemic Inflammatory Response Syndrome. Journal of Veterinary Emergency and Critical Care, 2026. DOI: 10.1111/vec.70167
Условия использования: Creative Commons Attribution (CC BY 4.0): https://creativecommons.org/licenses/by/4.0/ Лицензия источника
Design
Prospective, observational study.
Setting
University teaching hospital.
Animals
Client‐owned dogs were enrolled into three different groups: SIRS (30 dogs), non‐SIRS (25), and healthy controls (19). Dogs with acute critical illness (<48 h) admitted to the ICU were enrolled and classified into SIRS and non‐SIRS groups. Healthy dogs were enrolled as controls. Resting serum cortisol concentrations were measured before treatment. APPLE full and fast scores were calculated at admission, with outcome recorded for each dog.
Interventions
None.Связь с утверждением: подтверждает · полный текст · DOI 10.1111/vec.70167 · опубликован 25 сентября 2026
Resting Cortisol Concentration as a Predictor of Illness Severity in Critically Ill Dogs With Systemic Inflammatory Response Syndrome.
Точное место: 2 Materials and Methods → 2.1 Animals: критерии включения, исключения и запланированная выборка
Источник: Andreza Conti‐Patara, Linda G. Martin. Resting Cortisol Concentration as a Predictor of Illness Severity in Critically Ill Dogs With Systemic Inflammatory Response Syndrome. Journal of Veterinary Emergency and Critical Care, 2026. DOI: 10.1111/vec.70167
Условия использования: Creative Commons Attribution (CC BY 4.0): https://creativecommons.org/licenses/by/4.0/ Лицензия источника
This was an observational, prospective study of dogs over 12 months of age with acute critical illnesses (illness present for <48 h) admitted to a university teaching hospital's small animal ICU from January of 2017 to October of 2018. The study was approved by the Institutional Animal Care and Use Committee, and all dogs were enrolled with written consent from their owners. Sixty client‐owned dogs were eligible for the study and were classified into SIRS and non‐SIRS groups based on the systemic inflammatory response variables of hypothermia (<38.1°C [100.6°F]) or hyperthermia (>39.2°C [102.6°F]), tachycardia (heart rate >120/min), tachypnea (respiratory rate >20/min), leukocytosis (>16 × 10^3 cells/µL), leukopenia (<6 × 10^3 cells/µL), or >3% bands on the WBC count. Based on the definition, patients with two or more criteria and an appropriate underlying condition are considered to have SIRS [12, 13]. To enhance the identification of critically ill patients, the current study considered patients with three or more SIRS variables to have SIRS [14]. Dogs that received exogenous corticosteroids, etomidate, or ketoconazole within the last 4 weeks, and dogs with known malignancies or diseases that involved the pituitary or adrenal glands, were excluded from the study in accordance with the exclusion criteria of a previous study [15]. Five dogs were euthanized shortly after ICU admission due to financial constraints and were excluded from the study, leaving 30 dogs in the SIRS group and 25 dogs in the non‐SIRS group. Additionally, 19 healthy client‐owned dogs that presented to the university teaching hospital's Community Practice service were enrolled as controls. These dogs were presented for elective periodontal treatment, and the relevant data were obtained on the preanesthetic evaluation. The same eligibility criteria were used for the control group as the SIRS and non‐SIRS groups. Dogs were classified as healthy based on history, physical examination, CBC, and serum biochemistry results. A power analysis was conducted before the study, indicating that 150 dogs should be included and distributed equally across the groups. However, due to an insufficient caseload and a specific inclusion criterion, a total of 74 dogs were ultimately enrolled.Связь с утверждением: подтверждает · полный текст · DOI 10.1111/vec.70167 · опубликован 25 сентября 2026
Resting Cortisol Concentration as a Predictor of Illness Severity in Critically Ill Dogs With Systemic Inflammatory Response Syndrome.
Точное место: 4 Discussion: абзац «The current study also showed», неоднородность заболеваний, малая выборка и отсутствие повторных измерений
Источник: Andreza Conti‐Patara, Linda G. Martin. Resting Cortisol Concentration as a Predictor of Illness Severity in Critically Ill Dogs With Systemic Inflammatory Response Syndrome. Journal of Veterinary Emergency and Critical Care, 2026. DOI: 10.1111/vec.70167
Условия использования: Creative Commons Attribution (CC BY 4.0): https://creativecommons.org/licenses/by/4.0/ Лицензия источника
The current study also showed that nonsurvivors often presented with numerically higher resting serum cortisol concentrations than survivors. However, no statistical difference was found between the two groups, which agrees with previous studies [7, 8, 18]. Resting serum cortisol concentrations did not predict mortality, likely due to the variability of disease processes and the small number of cases enrolled in each group. Serum cortisol concentration was a good predictor of outcome in dogs with parvoviral enteritis when resting serum cortisol was measured at 24 and 48 h of hospitalization [8] and at 72 h of hospitalization [7]. The current study did not evaluate resting serum cortisol concentrations at different time points; however, it may indicate that resting serum cortisol concentrations measured at times other than admission to the hospital may be more helpful in determining patient outcomes.Связь с утверждением: подтверждает · полный текст · DOI 10.1111/vec.70167 · опубликован 25 сентября 2026
Умерли 12 из 30 собак группы SIRS и 4 из 25 собак группы сравнения с острым критическим заболеванием. Эти числа описывают конкретные группы исследования; переносить их на отдельную собаку как её вероятность исхода нельзя.
На чём основано
В этой выборке не получили статистических свидетельств того, что добавление кортизола при поступлении улучшает прогноз смертности по сравнению с моделью, учитывающей только группу (p = 0,33). Для добавления APPLE_full авторы сообщили умеренные статистические свидетельства улучшения прогноза (p = 0,03).
Граница вывода: Отсутствие статистических свидетельств улучшения не доказывает отсутствие прогностической связи в любой популяции. Результат относится к измерению при поступлении, выбранным группам и исходу до выписки; он не задаёт индивидуальную вероятность выживания.
Resting Cortisol Concentration as a Predictor of Illness Severity in Critically Ill Dogs With Systemic Inflammatory Response Syndrome.
Точное место: 2 Materials and Methods → 2.5 Outcome: определение исхода и лечение
Источник: Andreza Conti‐Patara, Linda G. Martin. Resting Cortisol Concentration as a Predictor of Illness Severity in Critically Ill Dogs With Systemic Inflammatory Response Syndrome. Journal of Veterinary Emergency and Critical Care, 2026. DOI: 10.1111/vec.70167
Условия использования: Creative Commons Attribution (CC BY 4.0): https://creativecommons.org/licenses/by/4.0/ Лицензия источника
Outcome was recorded as survival to hospital discharge or nonsurvival. All dogs that did not survive died of natural causes; dogs that were euthanized were excluded from the study. The treatment of each dog enrolled in the study was determined by its primary clinician.Связь с утверждением: подтверждает · полный текст · DOI 10.1111/vec.70167 · опубликован 25 сентября 2026
Resting Cortisol Concentration as a Predictor of Illness Severity in Critically Ill Dogs With Systemic Inflammatory Response Syndrome.
Точное место: 3 Results: абзац после Figure 1, число умерших и сравнение моделей прогноза смертности
Источник: Andreza Conti‐Patara, Linda G. Martin. Resting Cortisol Concentration as a Predictor of Illness Severity in Critically Ill Dogs With Systemic Inflammatory Response Syndrome. Journal of Veterinary Emergency and Critical Care, 2026. DOI: 10.1111/vec.70167
Условия использования: Creative Commons Attribution (CC BY 4.0): https://creativecommons.org/licenses/by/4.0/ Лицензия источника
Twelve of 30 dogs in the SIRS group and four of 25 dogs in the non‐SIRS group died. Resting serum cortisol concentrations tended to be higher in nonsurvivors (452.50 nmol/L; range: 162–1380 nmol/L [16.4 µg/dL; range: 5.8–50 µg/dL]) compared with survivors in the SIRS group (274.5 nmol/L; range: 73–1222 nmol/L [9.9 µg/dL; range: 2.6–44.2 µg/dL]); however, they were not significantly different (p = 0.1). In the non‐SIRS group, resting serum cortisol concentrations were the same in nonsurvivors (208.5 nmol/L; range: 121–494 [7.5 µg/dL, range: 4.3–17.9 µg/dL]) as in survivors (219 nmol/L; range: 74–861 [7.9 µg/dL; range: 2.6–31.2 µg/dL]; p = 0.9). The likelihood ratio tests were performed to assess the significance of the predictive outcomes of APPLE_full and APPLE_fast scores and resting serum cortisol concentration and to compare them with the model with only the group. There was no evidence that including APPLE_fast (p = 0.14) or resting serum cortisol concentration (p = 0.33) improves outcome prediction compared with a model with group factor alone. There was moderate evidence that including APPLE_full scores (p = 0.03) improves predictions of mortality.Связь с утверждением: подтверждает · полный текст · DOI 10.1111/vec.70167 · опубликован 25 сентября 2026
Почему вывод нельзя расширять
- Планировали 150 собак, но включили 74: группы оказались меньше предусмотренных расчётом.
- Работа выполнена в одной клинике; у пациентов были разные заболевания и действовали критерии отбора.
- Пять собак, подвергнутых эвтаназии вскоре после поступления по финансовым причинам, исключили. Итоговые исходы относятся к оставшейся выборке.
- Изучался анализ при поступлении. Результат не подтверждает пользу повторных измерений в ходе госпитализации.
- Наблюдательный дизайн не устанавливает, что повышение кортизола вызывает ухудшение или что его изменение улучшает исход.
- Неподтверждённое улучшение прогноза в небольшой выборке не доказывает отсутствия любой связи кортизола с исходом.
На чём основано · 1
В проспективное наблюдательное исследование в университетской ветеринарной клинике включили 74 собаки: 30 с синдромом системного воспалительного ответа (SIRS), 25 с острым критическим заболеванием без SIRS и 19 здоровых контрольных собак. Кортизол измеряли при поступлении до лечения; вмешательство исследователями не назначалось.
Граница вывода: Наблюдательный дизайн не устанавливает причинность. Выбранные авторами критерии SIRS и условия интенсивной терапии ограничивают перенос результатов.
Resting Cortisol Concentration as a Predictor of Illness Severity in Critically Ill Dogs With Systemic Inflammatory Response Syndrome.
Точное место: ABSTRACT: Design, Setting, Animals, Interventions
Источник: Andreza Conti‐Patara, Linda G. Martin. Resting Cortisol Concentration as a Predictor of Illness Severity in Critically Ill Dogs With Systemic Inflammatory Response Syndrome. Journal of Veterinary Emergency and Critical Care, 2026. DOI: 10.1111/vec.70167
Условия использования: Creative Commons Attribution (CC BY 4.0): https://creativecommons.org/licenses/by/4.0/ Лицензия источника
Design
Prospective, observational study.
Setting
University teaching hospital.
Animals
Client‐owned dogs were enrolled into three different groups: SIRS (30 dogs), non‐SIRS (25), and healthy controls (19). Dogs with acute critical illness (<48 h) admitted to the ICU were enrolled and classified into SIRS and non‐SIRS groups. Healthy dogs were enrolled as controls. Resting serum cortisol concentrations were measured before treatment. APPLE full and fast scores were calculated at admission, with outcome recorded for each dog.
Interventions
None.Связь с утверждением: подтверждает · полный текст · DOI 10.1111/vec.70167 · опубликован 25 сентября 2026
Resting Cortisol Concentration as a Predictor of Illness Severity in Critically Ill Dogs With Systemic Inflammatory Response Syndrome.
Точное место: 2 Materials and Methods → 2.1 Animals: критерии включения, исключения и запланированная выборка
Источник: Andreza Conti‐Patara, Linda G. Martin. Resting Cortisol Concentration as a Predictor of Illness Severity in Critically Ill Dogs With Systemic Inflammatory Response Syndrome. Journal of Veterinary Emergency and Critical Care, 2026. DOI: 10.1111/vec.70167
Условия использования: Creative Commons Attribution (CC BY 4.0): https://creativecommons.org/licenses/by/4.0/ Лицензия источника
This was an observational, prospective study of dogs over 12 months of age with acute critical illnesses (illness present for <48 h) admitted to a university teaching hospital's small animal ICU from January of 2017 to October of 2018. The study was approved by the Institutional Animal Care and Use Committee, and all dogs were enrolled with written consent from their owners. Sixty client‐owned dogs were eligible for the study and were classified into SIRS and non‐SIRS groups based on the systemic inflammatory response variables of hypothermia (<38.1°C [100.6°F]) or hyperthermia (>39.2°C [102.6°F]), tachycardia (heart rate >120/min), tachypnea (respiratory rate >20/min), leukocytosis (>16 × 10^3 cells/µL), leukopenia (<6 × 10^3 cells/µL), or >3% bands on the WBC count. Based on the definition, patients with two or more criteria and an appropriate underlying condition are considered to have SIRS [12, 13]. To enhance the identification of critically ill patients, the current study considered patients with three or more SIRS variables to have SIRS [14]. Dogs that received exogenous corticosteroids, etomidate, or ketoconazole within the last 4 weeks, and dogs with known malignancies or diseases that involved the pituitary or adrenal glands, were excluded from the study in accordance with the exclusion criteria of a previous study [15]. Five dogs were euthanized shortly after ICU admission due to financial constraints and were excluded from the study, leaving 30 dogs in the SIRS group and 25 dogs in the non‐SIRS group. Additionally, 19 healthy client‐owned dogs that presented to the university teaching hospital's Community Practice service were enrolled as controls. These dogs were presented for elective periodontal treatment, and the relevant data were obtained on the preanesthetic evaluation. The same eligibility criteria were used for the control group as the SIRS and non‐SIRS groups. Dogs were classified as healthy based on history, physical examination, CBC, and serum biochemistry results. A power analysis was conducted before the study, indicating that 150 dogs should be included and distributed equally across the groups. However, due to an insufficient caseload and a specific inclusion criterion, a total of 74 dogs were ultimately enrolled.Связь с утверждением: подтверждает · полный текст · DOI 10.1111/vec.70167 · опубликован 25 сентября 2026
На чём основано · 2
В изученной выборке более высокой на 62,5 нмоль/л концентрации кортизола при поступлении соответствовал более высокий на 1 балл показатель тяжести состояния APPLE_full; 95%-й доверительный интервал оценки составлял 0,6–1,4 балла.
Граница вывода: Это статистическая связь с оценкой тяжести состояния, а не доказательство того, что кортизол вызывает ухудшение. Коэффициент регрессии не является порогом для решения о лечении или прогнозом для отдельной собаки. Наблюдение относится к измерению при поступлении и не описывает изменение показателей одной собаки во времени.
Resting Cortisol Concentration as a Predictor of Illness Severity in Critically Ill Dogs With Systemic Inflammatory Response Syndrome.
Точное место: ABSTRACT: Design, Setting, Animals, Interventions
Источник: Andreza Conti‐Patara, Linda G. Martin. Resting Cortisol Concentration as a Predictor of Illness Severity in Critically Ill Dogs With Systemic Inflammatory Response Syndrome. Journal of Veterinary Emergency and Critical Care, 2026. DOI: 10.1111/vec.70167
Условия использования: Creative Commons Attribution (CC BY 4.0): https://creativecommons.org/licenses/by/4.0/ Лицензия источника
Design
Prospective, observational study.
Setting
University teaching hospital.
Animals
Client‐owned dogs were enrolled into three different groups: SIRS (30 dogs), non‐SIRS (25), and healthy controls (19). Dogs with acute critical illness (<48 h) admitted to the ICU were enrolled and classified into SIRS and non‐SIRS groups. Healthy dogs were enrolled as controls. Resting serum cortisol concentrations were measured before treatment. APPLE full and fast scores were calculated at admission, with outcome recorded for each dog.
Interventions
None.Связь с утверждением: подтверждает · полный текст · DOI 10.1111/vec.70167 · опубликован 25 сентября 2026
Resting Cortisol Concentration as a Predictor of Illness Severity in Critically Ill Dogs With Systemic Inflammatory Response Syndrome.
Точное место: 3 Results: абзац непосредственно перед Figure 2, связь кортизола с APPLE_full
Источник: Andreza Conti‐Patara, Linda G. Martin. Resting Cortisol Concentration as a Predictor of Illness Severity in Critically Ill Dogs With Systemic Inflammatory Response Syndrome. Journal of Veterinary Emergency and Critical Care, 2026. DOI: 10.1111/vec.70167
Условия использования: Creative Commons Attribution (CC BY 4.0): https://creativecommons.org/licenses/by/4.0/ Лицензия источника
The APPLE_full scores increased by 1 (95% confidence interval [CI]: 0.6–1.4) for every increase of 62.5 nmol/L (2.2 µg/dL) in resting serum cortisol concentration (Figure 2).Связь с утверждением: подтверждает · полный текст · DOI 10.1111/vec.70167 · опубликован 25 сентября 2026
Resting Cortisol Concentration as a Predictor of Illness Severity in Critically Ill Dogs With Systemic Inflammatory Response Syndrome.
Точное место: 3 Results: абзац после Figure 1, предложение о составе регрессионной модели APPLE_full перед Table 1
Источник: Andreza Conti‐Patara, Linda G. Martin. Resting Cortisol Concentration as a Predictor of Illness Severity in Critically Ill Dogs With Systemic Inflammatory Response Syndrome. Journal of Veterinary Emergency and Critical Care, 2026. DOI: 10.1111/vec.70167
Условия использования: Creative Commons Attribution (CC BY 4.0): https://creativecommons.org/licenses/by/4.0/ Лицензия источника
A linear regression model was fit to relate the APPLE_full score to the three groups and resting serum cortisol concentration at the time of hospital admission (Table 1).Связь с утверждением: подтверждает · полный текст · DOI 10.1111/vec.70167 · опубликован 25 сентября 2026
На чём основано · 3
В этой выборке не получили статистических свидетельств того, что добавление кортизола при поступлении улучшает прогноз смертности по сравнению с моделью, учитывающей только группу (p = 0,33). Для добавления APPLE_full авторы сообщили умеренные статистические свидетельства улучшения прогноза (p = 0,03).
Граница вывода: Отсутствие статистических свидетельств улучшения не доказывает отсутствие прогностической связи в любой популяции. Результат относится к измерению при поступлении, выбранным группам и исходу до выписки; он не задаёт индивидуальную вероятность выживания.
Resting Cortisol Concentration as a Predictor of Illness Severity in Critically Ill Dogs With Systemic Inflammatory Response Syndrome.
Точное место: 2 Materials and Methods → 2.5 Outcome: определение исхода и лечение
Источник: Andreza Conti‐Patara, Linda G. Martin. Resting Cortisol Concentration as a Predictor of Illness Severity in Critically Ill Dogs With Systemic Inflammatory Response Syndrome. Journal of Veterinary Emergency and Critical Care, 2026. DOI: 10.1111/vec.70167
Условия использования: Creative Commons Attribution (CC BY 4.0): https://creativecommons.org/licenses/by/4.0/ Лицензия источника
Outcome was recorded as survival to hospital discharge or nonsurvival. All dogs that did not survive died of natural causes; dogs that were euthanized were excluded from the study. The treatment of each dog enrolled in the study was determined by its primary clinician.Связь с утверждением: подтверждает · полный текст · DOI 10.1111/vec.70167 · опубликован 25 сентября 2026
Resting Cortisol Concentration as a Predictor of Illness Severity in Critically Ill Dogs With Systemic Inflammatory Response Syndrome.
Точное место: 3 Results: абзац после Figure 1, число умерших и сравнение моделей прогноза смертности
Источник: Andreza Conti‐Patara, Linda G. Martin. Resting Cortisol Concentration as a Predictor of Illness Severity in Critically Ill Dogs With Systemic Inflammatory Response Syndrome. Journal of Veterinary Emergency and Critical Care, 2026. DOI: 10.1111/vec.70167
Условия использования: Creative Commons Attribution (CC BY 4.0): https://creativecommons.org/licenses/by/4.0/ Лицензия источника
Twelve of 30 dogs in the SIRS group and four of 25 dogs in the non‐SIRS group died. Resting serum cortisol concentrations tended to be higher in nonsurvivors (452.50 nmol/L; range: 162–1380 nmol/L [16.4 µg/dL; range: 5.8–50 µg/dL]) compared with survivors in the SIRS group (274.5 nmol/L; range: 73–1222 nmol/L [9.9 µg/dL; range: 2.6–44.2 µg/dL]); however, they were not significantly different (p = 0.1). In the non‐SIRS group, resting serum cortisol concentrations were the same in nonsurvivors (208.5 nmol/L; range: 121–494 [7.5 µg/dL, range: 4.3–17.9 µg/dL]) as in survivors (219 nmol/L; range: 74–861 [7.9 µg/dL; range: 2.6–31.2 µg/dL]; p = 0.9). The likelihood ratio tests were performed to assess the significance of the predictive outcomes of APPLE_full and APPLE_fast scores and resting serum cortisol concentration and to compare them with the model with only the group. There was no evidence that including APPLE_fast (p = 0.14) or resting serum cortisol concentration (p = 0.33) improves outcome prediction compared with a model with group factor alone. There was moderate evidence that including APPLE_full scores (p = 0.03) improves predictions of mortality.Связь с утверждением: подтверждает · полный текст · DOI 10.1111/vec.70167 · опубликован 25 сентября 2026
На чём основано · 4
До начала исследования расчёт предусматривал 150 собак, но включили 74. Пять собак, эвтаназированных вскоре после поступления по финансовым причинам, исключили. Авторы также отмечают неоднородность заболеваний, малые группы и отсутствие оценки кортизола в разные моменты госпитализации.
Граница вывода: Малые неоднородные группы ограничивают статистическую мощность и перенос результатов. Исключение эвтаназированных собак ограничивает применимость описанного исхода ко всем поступающим пациентам. Причинный эффект кортизола и преимущества изменения лечения не проверялись.
Resting Cortisol Concentration as a Predictor of Illness Severity in Critically Ill Dogs With Systemic Inflammatory Response Syndrome.
Точное место: ABSTRACT: Design, Setting, Animals, Interventions
Источник: Andreza Conti‐Patara, Linda G. Martin. Resting Cortisol Concentration as a Predictor of Illness Severity in Critically Ill Dogs With Systemic Inflammatory Response Syndrome. Journal of Veterinary Emergency and Critical Care, 2026. DOI: 10.1111/vec.70167
Условия использования: Creative Commons Attribution (CC BY 4.0): https://creativecommons.org/licenses/by/4.0/ Лицензия источника
Design
Prospective, observational study.
Setting
University teaching hospital.
Animals
Client‐owned dogs were enrolled into three different groups: SIRS (30 dogs), non‐SIRS (25), and healthy controls (19). Dogs with acute critical illness (<48 h) admitted to the ICU were enrolled and classified into SIRS and non‐SIRS groups. Healthy dogs were enrolled as controls. Resting serum cortisol concentrations were measured before treatment. APPLE full and fast scores were calculated at admission, with outcome recorded for each dog.
Interventions
None.Связь с утверждением: подтверждает · полный текст · DOI 10.1111/vec.70167 · опубликован 25 сентября 2026
Resting Cortisol Concentration as a Predictor of Illness Severity in Critically Ill Dogs With Systemic Inflammatory Response Syndrome.
Точное место: 2 Materials and Methods → 2.1 Animals: критерии включения, исключения и запланированная выборка
Источник: Andreza Conti‐Patara, Linda G. Martin. Resting Cortisol Concentration as a Predictor of Illness Severity in Critically Ill Dogs With Systemic Inflammatory Response Syndrome. Journal of Veterinary Emergency and Critical Care, 2026. DOI: 10.1111/vec.70167
Условия использования: Creative Commons Attribution (CC BY 4.0): https://creativecommons.org/licenses/by/4.0/ Лицензия источника
This was an observational, prospective study of dogs over 12 months of age with acute critical illnesses (illness present for <48 h) admitted to a university teaching hospital's small animal ICU from January of 2017 to October of 2018. The study was approved by the Institutional Animal Care and Use Committee, and all dogs were enrolled with written consent from their owners. Sixty client‐owned dogs were eligible for the study and were classified into SIRS and non‐SIRS groups based on the systemic inflammatory response variables of hypothermia (<38.1°C [100.6°F]) or hyperthermia (>39.2°C [102.6°F]), tachycardia (heart rate >120/min), tachypnea (respiratory rate >20/min), leukocytosis (>16 × 10^3 cells/µL), leukopenia (<6 × 10^3 cells/µL), or >3% bands on the WBC count. Based on the definition, patients with two or more criteria and an appropriate underlying condition are considered to have SIRS [12, 13]. To enhance the identification of critically ill patients, the current study considered patients with three or more SIRS variables to have SIRS [14]. Dogs that received exogenous corticosteroids, etomidate, or ketoconazole within the last 4 weeks, and dogs with known malignancies or diseases that involved the pituitary or adrenal glands, were excluded from the study in accordance with the exclusion criteria of a previous study [15]. Five dogs were euthanized shortly after ICU admission due to financial constraints and were excluded from the study, leaving 30 dogs in the SIRS group and 25 dogs in the non‐SIRS group. Additionally, 19 healthy client‐owned dogs that presented to the university teaching hospital's Community Practice service were enrolled as controls. These dogs were presented for elective periodontal treatment, and the relevant data were obtained on the preanesthetic evaluation. The same eligibility criteria were used for the control group as the SIRS and non‐SIRS groups. Dogs were classified as healthy based on history, physical examination, CBC, and serum biochemistry results. A power analysis was conducted before the study, indicating that 150 dogs should be included and distributed equally across the groups. However, due to an insufficient caseload and a specific inclusion criterion, a total of 74 dogs were ultimately enrolled.Связь с утверждением: подтверждает · полный текст · DOI 10.1111/vec.70167 · опубликован 25 сентября 2026
Resting Cortisol Concentration as a Predictor of Illness Severity in Critically Ill Dogs With Systemic Inflammatory Response Syndrome.
Точное место: 4 Discussion: абзац «The current study also showed», неоднородность заболеваний, малая выборка и отсутствие повторных измерений
Источник: Andreza Conti‐Patara, Linda G. Martin. Resting Cortisol Concentration as a Predictor of Illness Severity in Critically Ill Dogs With Systemic Inflammatory Response Syndrome. Journal of Veterinary Emergency and Critical Care, 2026. DOI: 10.1111/vec.70167
Условия использования: Creative Commons Attribution (CC BY 4.0): https://creativecommons.org/licenses/by/4.0/ Лицензия источника
The current study also showed that nonsurvivors often presented with numerically higher resting serum cortisol concentrations than survivors. However, no statistical difference was found between the two groups, which agrees with previous studies [7, 8, 18]. Resting serum cortisol concentrations did not predict mortality, likely due to the variability of disease processes and the small number of cases enrolled in each group. Serum cortisol concentration was a good predictor of outcome in dogs with parvoviral enteritis when resting serum cortisol was measured at 24 and 48 h of hospitalization [8] and at 72 h of hospitalization [7]. The current study did not evaluate resting serum cortisol concentrations at different time points; however, it may indicate that resting serum cortisol concentrations measured at times other than admission to the hospital may be more helpful in determining patient outcomes.Связь с утверждением: подтверждает · полный текст · DOI 10.1111/vec.70167 · опубликован 25 сентября 2026
Что это значит для владельца
Работа различает тяжесть состояния сейчас и исход госпитализации. Связь кортизола с APPLE_full поддерживает первый вывод, но улучшение прогноза смертности по кортизолу не подтвердилось. Высокое значение само по себе не позволяет обещать выздоровление или считать исход предрешённым. Схем лечения и индивидуального прогностического порога исследование не устанавливает.
На чём основано · 1
В проспективное наблюдательное исследование в университетской ветеринарной клинике включили 74 собаки: 30 с синдромом системного воспалительного ответа (SIRS), 25 с острым критическим заболеванием без SIRS и 19 здоровых контрольных собак. Кортизол измеряли при поступлении до лечения; вмешательство исследователями не назначалось.
Граница вывода: Наблюдательный дизайн не устанавливает причинность. Выбранные авторами критерии SIRS и условия интенсивной терапии ограничивают перенос результатов.
Resting Cortisol Concentration as a Predictor of Illness Severity in Critically Ill Dogs With Systemic Inflammatory Response Syndrome.
Точное место: ABSTRACT: Design, Setting, Animals, Interventions
Источник: Andreza Conti‐Patara, Linda G. Martin. Resting Cortisol Concentration as a Predictor of Illness Severity in Critically Ill Dogs With Systemic Inflammatory Response Syndrome. Journal of Veterinary Emergency and Critical Care, 2026. DOI: 10.1111/vec.70167
Условия использования: Creative Commons Attribution (CC BY 4.0): https://creativecommons.org/licenses/by/4.0/ Лицензия источника
Design
Prospective, observational study.
Setting
University teaching hospital.
Animals
Client‐owned dogs were enrolled into three different groups: SIRS (30 dogs), non‐SIRS (25), and healthy controls (19). Dogs with acute critical illness (<48 h) admitted to the ICU were enrolled and classified into SIRS and non‐SIRS groups. Healthy dogs were enrolled as controls. Resting serum cortisol concentrations were measured before treatment. APPLE full and fast scores were calculated at admission, with outcome recorded for each dog.
Interventions
None.Связь с утверждением: подтверждает · полный текст · DOI 10.1111/vec.70167 · опубликован 25 сентября 2026
Resting Cortisol Concentration as a Predictor of Illness Severity in Critically Ill Dogs With Systemic Inflammatory Response Syndrome.
Точное место: 2 Materials and Methods → 2.1 Animals: критерии включения, исключения и запланированная выборка
Источник: Andreza Conti‐Patara, Linda G. Martin. Resting Cortisol Concentration as a Predictor of Illness Severity in Critically Ill Dogs With Systemic Inflammatory Response Syndrome. Journal of Veterinary Emergency and Critical Care, 2026. DOI: 10.1111/vec.70167
Условия использования: Creative Commons Attribution (CC BY 4.0): https://creativecommons.org/licenses/by/4.0/ Лицензия источника
This was an observational, prospective study of dogs over 12 months of age with acute critical illnesses (illness present for <48 h) admitted to a university teaching hospital's small animal ICU from January of 2017 to October of 2018. The study was approved by the Institutional Animal Care and Use Committee, and all dogs were enrolled with written consent from their owners. Sixty client‐owned dogs were eligible for the study and were classified into SIRS and non‐SIRS groups based on the systemic inflammatory response variables of hypothermia (<38.1°C [100.6°F]) or hyperthermia (>39.2°C [102.6°F]), tachycardia (heart rate >120/min), tachypnea (respiratory rate >20/min), leukocytosis (>16 × 10^3 cells/µL), leukopenia (<6 × 10^3 cells/µL), or >3% bands on the WBC count. Based on the definition, patients with two or more criteria and an appropriate underlying condition are considered to have SIRS [12, 13]. To enhance the identification of critically ill patients, the current study considered patients with three or more SIRS variables to have SIRS [14]. Dogs that received exogenous corticosteroids, etomidate, or ketoconazole within the last 4 weeks, and dogs with known malignancies or diseases that involved the pituitary or adrenal glands, were excluded from the study in accordance with the exclusion criteria of a previous study [15]. Five dogs were euthanized shortly after ICU admission due to financial constraints and were excluded from the study, leaving 30 dogs in the SIRS group and 25 dogs in the non‐SIRS group. Additionally, 19 healthy client‐owned dogs that presented to the university teaching hospital's Community Practice service were enrolled as controls. These dogs were presented for elective periodontal treatment, and the relevant data were obtained on the preanesthetic evaluation. The same eligibility criteria were used for the control group as the SIRS and non‐SIRS groups. Dogs were classified as healthy based on history, physical examination, CBC, and serum biochemistry results. A power analysis was conducted before the study, indicating that 150 dogs should be included and distributed equally across the groups. However, due to an insufficient caseload and a specific inclusion criterion, a total of 74 dogs were ultimately enrolled.Связь с утверждением: подтверждает · полный текст · DOI 10.1111/vec.70167 · опубликован 25 сентября 2026
На чём основано · 2
В изученной выборке более высокой на 62,5 нмоль/л концентрации кортизола при поступлении соответствовал более высокий на 1 балл показатель тяжести состояния APPLE_full; 95%-й доверительный интервал оценки составлял 0,6–1,4 балла.
Граница вывода: Это статистическая связь с оценкой тяжести состояния, а не доказательство того, что кортизол вызывает ухудшение. Коэффициент регрессии не является порогом для решения о лечении или прогнозом для отдельной собаки. Наблюдение относится к измерению при поступлении и не описывает изменение показателей одной собаки во времени.
Resting Cortisol Concentration as a Predictor of Illness Severity in Critically Ill Dogs With Systemic Inflammatory Response Syndrome.
Точное место: ABSTRACT: Design, Setting, Animals, Interventions
Источник: Andreza Conti‐Patara, Linda G. Martin. Resting Cortisol Concentration as a Predictor of Illness Severity in Critically Ill Dogs With Systemic Inflammatory Response Syndrome. Journal of Veterinary Emergency and Critical Care, 2026. DOI: 10.1111/vec.70167
Условия использования: Creative Commons Attribution (CC BY 4.0): https://creativecommons.org/licenses/by/4.0/ Лицензия источника
Design
Prospective, observational study.
Setting
University teaching hospital.
Animals
Client‐owned dogs were enrolled into three different groups: SIRS (30 dogs), non‐SIRS (25), and healthy controls (19). Dogs with acute critical illness (<48 h) admitted to the ICU were enrolled and classified into SIRS and non‐SIRS groups. Healthy dogs were enrolled as controls. Resting serum cortisol concentrations were measured before treatment. APPLE full and fast scores were calculated at admission, with outcome recorded for each dog.
Interventions
None.Связь с утверждением: подтверждает · полный текст · DOI 10.1111/vec.70167 · опубликован 25 сентября 2026
Resting Cortisol Concentration as a Predictor of Illness Severity in Critically Ill Dogs With Systemic Inflammatory Response Syndrome.
Точное место: 3 Results: абзац непосредственно перед Figure 2, связь кортизола с APPLE_full
Источник: Andreza Conti‐Patara, Linda G. Martin. Resting Cortisol Concentration as a Predictor of Illness Severity in Critically Ill Dogs With Systemic Inflammatory Response Syndrome. Journal of Veterinary Emergency and Critical Care, 2026. DOI: 10.1111/vec.70167
Условия использования: Creative Commons Attribution (CC BY 4.0): https://creativecommons.org/licenses/by/4.0/ Лицензия источника
The APPLE_full scores increased by 1 (95% confidence interval [CI]: 0.6–1.4) for every increase of 62.5 nmol/L (2.2 µg/dL) in resting serum cortisol concentration (Figure 2).Связь с утверждением: подтверждает · полный текст · DOI 10.1111/vec.70167 · опубликован 25 сентября 2026
Resting Cortisol Concentration as a Predictor of Illness Severity in Critically Ill Dogs With Systemic Inflammatory Response Syndrome.
Точное место: 3 Results: абзац после Figure 1, предложение о составе регрессионной модели APPLE_full перед Table 1
Источник: Andreza Conti‐Patara, Linda G. Martin. Resting Cortisol Concentration as a Predictor of Illness Severity in Critically Ill Dogs With Systemic Inflammatory Response Syndrome. Journal of Veterinary Emergency and Critical Care, 2026. DOI: 10.1111/vec.70167
Условия использования: Creative Commons Attribution (CC BY 4.0): https://creativecommons.org/licenses/by/4.0/ Лицензия источника
A linear regression model was fit to relate the APPLE_full score to the three groups and resting serum cortisol concentration at the time of hospital admission (Table 1).Связь с утверждением: подтверждает · полный текст · DOI 10.1111/vec.70167 · опубликован 25 сентября 2026
На чём основано · 3
В этой выборке не получили статистических свидетельств того, что добавление кортизола при поступлении улучшает прогноз смертности по сравнению с моделью, учитывающей только группу (p = 0,33). Для добавления APPLE_full авторы сообщили умеренные статистические свидетельства улучшения прогноза (p = 0,03).
Граница вывода: Отсутствие статистических свидетельств улучшения не доказывает отсутствие прогностической связи в любой популяции. Результат относится к измерению при поступлении, выбранным группам и исходу до выписки; он не задаёт индивидуальную вероятность выживания.
Resting Cortisol Concentration as a Predictor of Illness Severity in Critically Ill Dogs With Systemic Inflammatory Response Syndrome.
Точное место: 2 Materials and Methods → 2.5 Outcome: определение исхода и лечение
Источник: Andreza Conti‐Patara, Linda G. Martin. Resting Cortisol Concentration as a Predictor of Illness Severity in Critically Ill Dogs With Systemic Inflammatory Response Syndrome. Journal of Veterinary Emergency and Critical Care, 2026. DOI: 10.1111/vec.70167
Условия использования: Creative Commons Attribution (CC BY 4.0): https://creativecommons.org/licenses/by/4.0/ Лицензия источника
Outcome was recorded as survival to hospital discharge or nonsurvival. All dogs that did not survive died of natural causes; dogs that were euthanized were excluded from the study. The treatment of each dog enrolled in the study was determined by its primary clinician.Связь с утверждением: подтверждает · полный текст · DOI 10.1111/vec.70167 · опубликован 25 сентября 2026
Resting Cortisol Concentration as a Predictor of Illness Severity in Critically Ill Dogs With Systemic Inflammatory Response Syndrome.
Точное место: 3 Results: абзац после Figure 1, число умерших и сравнение моделей прогноза смертности
Источник: Andreza Conti‐Patara, Linda G. Martin. Resting Cortisol Concentration as a Predictor of Illness Severity in Critically Ill Dogs With Systemic Inflammatory Response Syndrome. Journal of Veterinary Emergency and Critical Care, 2026. DOI: 10.1111/vec.70167
Условия использования: Creative Commons Attribution (CC BY 4.0): https://creativecommons.org/licenses/by/4.0/ Лицензия источника
Twelve of 30 dogs in the SIRS group and four of 25 dogs in the non‐SIRS group died. Resting serum cortisol concentrations tended to be higher in nonsurvivors (452.50 nmol/L; range: 162–1380 nmol/L [16.4 µg/dL; range: 5.8–50 µg/dL]) compared with survivors in the SIRS group (274.5 nmol/L; range: 73–1222 nmol/L [9.9 µg/dL; range: 2.6–44.2 µg/dL]); however, they were not significantly different (p = 0.1). In the non‐SIRS group, resting serum cortisol concentrations were the same in nonsurvivors (208.5 nmol/L; range: 121–494 [7.5 µg/dL, range: 4.3–17.9 µg/dL]) as in survivors (219 nmol/L; range: 74–861 [7.9 µg/dL; range: 2.6–31.2 µg/dL]; p = 0.9). The likelihood ratio tests were performed to assess the significance of the predictive outcomes of APPLE_full and APPLE_fast scores and resting serum cortisol concentration and to compare them with the model with only the group. There was no evidence that including APPLE_fast (p = 0.14) or resting serum cortisol concentration (p = 0.33) improves outcome prediction compared with a model with group factor alone. There was moderate evidence that including APPLE_full scores (p = 0.03) improves predictions of mortality.Связь с утверждением: подтверждает · полный текст · DOI 10.1111/vec.70167 · опубликован 25 сентября 2026
На чём основано · 4
До начала исследования расчёт предусматривал 150 собак, но включили 74. Пять собак, эвтаназированных вскоре после поступления по финансовым причинам, исключили. Авторы также отмечают неоднородность заболеваний, малые группы и отсутствие оценки кортизола в разные моменты госпитализации.
Граница вывода: Малые неоднородные группы ограничивают статистическую мощность и перенос результатов. Исключение эвтаназированных собак ограничивает применимость описанного исхода ко всем поступающим пациентам. Причинный эффект кортизола и преимущества изменения лечения не проверялись.
Resting Cortisol Concentration as a Predictor of Illness Severity in Critically Ill Dogs With Systemic Inflammatory Response Syndrome.
Точное место: ABSTRACT: Design, Setting, Animals, Interventions
Источник: Andreza Conti‐Patara, Linda G. Martin. Resting Cortisol Concentration as a Predictor of Illness Severity in Critically Ill Dogs With Systemic Inflammatory Response Syndrome. Journal of Veterinary Emergency and Critical Care, 2026. DOI: 10.1111/vec.70167
Условия использования: Creative Commons Attribution (CC BY 4.0): https://creativecommons.org/licenses/by/4.0/ Лицензия источника
Design
Prospective, observational study.
Setting
University teaching hospital.
Animals
Client‐owned dogs were enrolled into three different groups: SIRS (30 dogs), non‐SIRS (25), and healthy controls (19). Dogs with acute critical illness (<48 h) admitted to the ICU were enrolled and classified into SIRS and non‐SIRS groups. Healthy dogs were enrolled as controls. Resting serum cortisol concentrations were measured before treatment. APPLE full and fast scores were calculated at admission, with outcome recorded for each dog.
Interventions
None.Связь с утверждением: подтверждает · полный текст · DOI 10.1111/vec.70167 · опубликован 25 сентября 2026
Resting Cortisol Concentration as a Predictor of Illness Severity in Critically Ill Dogs With Systemic Inflammatory Response Syndrome.
Точное место: 2 Materials and Methods → 2.1 Animals: критерии включения, исключения и запланированная выборка
Источник: Andreza Conti‐Patara, Linda G. Martin. Resting Cortisol Concentration as a Predictor of Illness Severity in Critically Ill Dogs With Systemic Inflammatory Response Syndrome. Journal of Veterinary Emergency and Critical Care, 2026. DOI: 10.1111/vec.70167
Условия использования: Creative Commons Attribution (CC BY 4.0): https://creativecommons.org/licenses/by/4.0/ Лицензия источника
This was an observational, prospective study of dogs over 12 months of age with acute critical illnesses (illness present for <48 h) admitted to a university teaching hospital's small animal ICU from January of 2017 to October of 2018. The study was approved by the Institutional Animal Care and Use Committee, and all dogs were enrolled with written consent from their owners. Sixty client‐owned dogs were eligible for the study and were classified into SIRS and non‐SIRS groups based on the systemic inflammatory response variables of hypothermia (<38.1°C [100.6°F]) or hyperthermia (>39.2°C [102.6°F]), tachycardia (heart rate >120/min), tachypnea (respiratory rate >20/min), leukocytosis (>16 × 10^3 cells/µL), leukopenia (<6 × 10^3 cells/µL), or >3% bands on the WBC count. Based on the definition, patients with two or more criteria and an appropriate underlying condition are considered to have SIRS [12, 13]. To enhance the identification of critically ill patients, the current study considered patients with three or more SIRS variables to have SIRS [14]. Dogs that received exogenous corticosteroids, etomidate, or ketoconazole within the last 4 weeks, and dogs with known malignancies or diseases that involved the pituitary or adrenal glands, were excluded from the study in accordance with the exclusion criteria of a previous study [15]. Five dogs were euthanized shortly after ICU admission due to financial constraints and were excluded from the study, leaving 30 dogs in the SIRS group and 25 dogs in the non‐SIRS group. Additionally, 19 healthy client‐owned dogs that presented to the university teaching hospital's Community Practice service were enrolled as controls. These dogs were presented for elective periodontal treatment, and the relevant data were obtained on the preanesthetic evaluation. The same eligibility criteria were used for the control group as the SIRS and non‐SIRS groups. Dogs were classified as healthy based on history, physical examination, CBC, and serum biochemistry results. A power analysis was conducted before the study, indicating that 150 dogs should be included and distributed equally across the groups. However, due to an insufficient caseload and a specific inclusion criterion, a total of 74 dogs were ultimately enrolled.Связь с утверждением: подтверждает · полный текст · DOI 10.1111/vec.70167 · опубликован 25 сентября 2026
Resting Cortisol Concentration as a Predictor of Illness Severity in Critically Ill Dogs With Systemic Inflammatory Response Syndrome.
Точное место: 4 Discussion: абзац «The current study also showed», неоднородность заболеваний, малая выборка и отсутствие повторных измерений
Источник: Andreza Conti‐Patara, Linda G. Martin. Resting Cortisol Concentration as a Predictor of Illness Severity in Critically Ill Dogs With Systemic Inflammatory Response Syndrome. Journal of Veterinary Emergency and Critical Care, 2026. DOI: 10.1111/vec.70167
Условия использования: Creative Commons Attribution (CC BY 4.0): https://creativecommons.org/licenses/by/4.0/ Лицензия источника
The current study also showed that nonsurvivors often presented with numerically higher resting serum cortisol concentrations than survivors. However, no statistical difference was found between the two groups, which agrees with previous studies [7, 8, 18]. Resting serum cortisol concentrations did not predict mortality, likely due to the variability of disease processes and the small number of cases enrolled in each group. Serum cortisol concentration was a good predictor of outcome in dogs with parvoviral enteritis when resting serum cortisol was measured at 24 and 48 h of hospitalization [8] and at 72 h of hospitalization [7]. The current study did not evaluate resting serum cortisol concentrations at different time points; however, it may indicate that resting serum cortisol concentrations measured at times other than admission to the hospital may be more helpful in determining patient outcomes.Связь с утверждением: подтверждает · полный текст · DOI 10.1111/vec.70167 · опубликован 25 сентября 2026
На чём основано · 1
В проспективное наблюдательное исследование в университетской ветеринарной клинике включили 74 собаки: 30 с синдромом системного воспалительного ответа (SIRS), 25 с острым критическим заболеванием без SIRS и 19 здоровых контрольных собак. Кортизол измеряли при поступлении до лечения; вмешательство исследователями не назначалось.
Граница вывода: Наблюдательный дизайн не устанавливает причинность. Выбранные авторами критерии SIRS и условия интенсивной терапии ограничивают перенос результатов.
Resting Cortisol Concentration as a Predictor of Illness Severity in Critically Ill Dogs With Systemic Inflammatory Response Syndrome.
Точное место: ABSTRACT: Design, Setting, Animals, Interventions
Источник: Andreza Conti‐Patara, Linda G. Martin. Resting Cortisol Concentration as a Predictor of Illness Severity in Critically Ill Dogs With Systemic Inflammatory Response Syndrome. Journal of Veterinary Emergency and Critical Care, 2026. DOI: 10.1111/vec.70167
Условия использования: Creative Commons Attribution (CC BY 4.0): https://creativecommons.org/licenses/by/4.0/ Лицензия источника
Design
Prospective, observational study.
Setting
University teaching hospital.
Animals
Client‐owned dogs were enrolled into three different groups: SIRS (30 dogs), non‐SIRS (25), and healthy controls (19). Dogs with acute critical illness (<48 h) admitted to the ICU were enrolled and classified into SIRS and non‐SIRS groups. Healthy dogs were enrolled as controls. Resting serum cortisol concentrations were measured before treatment. APPLE full and fast scores were calculated at admission, with outcome recorded for each dog.
Interventions
None.Связь с утверждением: подтверждает · полный текст · DOI 10.1111/vec.70167 · опубликован 25 сентября 2026
Resting Cortisol Concentration as a Predictor of Illness Severity in Critically Ill Dogs With Systemic Inflammatory Response Syndrome.
Точное место: 2 Materials and Methods → 2.1 Animals: критерии включения, исключения и запланированная выборка
Источник: Andreza Conti‐Patara, Linda G. Martin. Resting Cortisol Concentration as a Predictor of Illness Severity in Critically Ill Dogs With Systemic Inflammatory Response Syndrome. Journal of Veterinary Emergency and Critical Care, 2026. DOI: 10.1111/vec.70167
Условия использования: Creative Commons Attribution (CC BY 4.0): https://creativecommons.org/licenses/by/4.0/ Лицензия источника
This was an observational, prospective study of dogs over 12 months of age with acute critical illnesses (illness present for <48 h) admitted to a university teaching hospital's small animal ICU from January of 2017 to October of 2018. The study was approved by the Institutional Animal Care and Use Committee, and all dogs were enrolled with written consent from their owners. Sixty client‐owned dogs were eligible for the study and were classified into SIRS and non‐SIRS groups based on the systemic inflammatory response variables of hypothermia (<38.1°C [100.6°F]) or hyperthermia (>39.2°C [102.6°F]), tachycardia (heart rate >120/min), tachypnea (respiratory rate >20/min), leukocytosis (>16 × 10^3 cells/µL), leukopenia (<6 × 10^3 cells/µL), or >3% bands on the WBC count. Based on the definition, patients with two or more criteria and an appropriate underlying condition are considered to have SIRS [12, 13]. To enhance the identification of critically ill patients, the current study considered patients with three or more SIRS variables to have SIRS [14]. Dogs that received exogenous corticosteroids, etomidate, or ketoconazole within the last 4 weeks, and dogs with known malignancies or diseases that involved the pituitary or adrenal glands, were excluded from the study in accordance with the exclusion criteria of a previous study [15]. Five dogs were euthanized shortly after ICU admission due to financial constraints and were excluded from the study, leaving 30 dogs in the SIRS group and 25 dogs in the non‐SIRS group. Additionally, 19 healthy client‐owned dogs that presented to the university teaching hospital's Community Practice service were enrolled as controls. These dogs were presented for elective periodontal treatment, and the relevant data were obtained on the preanesthetic evaluation. The same eligibility criteria were used for the control group as the SIRS and non‐SIRS groups. Dogs were classified as healthy based on history, physical examination, CBC, and serum biochemistry results. A power analysis was conducted before the study, indicating that 150 dogs should be included and distributed equally across the groups. However, due to an insufficient caseload and a specific inclusion criterion, a total of 74 dogs were ultimately enrolled.Связь с утверждением: подтверждает · полный текст · DOI 10.1111/vec.70167 · опубликован 25 сентября 2026
На чём основано · 2
В этой выборке не получили статистических свидетельств того, что добавление кортизола при поступлении улучшает прогноз смертности по сравнению с моделью, учитывающей только группу (p = 0,33). Для добавления APPLE_full авторы сообщили умеренные статистические свидетельства улучшения прогноза (p = 0,03).
Граница вывода: Отсутствие статистических свидетельств улучшения не доказывает отсутствие прогностической связи в любой популяции. Результат относится к измерению при поступлении, выбранным группам и исходу до выписки; он не задаёт индивидуальную вероятность выживания.
Resting Cortisol Concentration as a Predictor of Illness Severity in Critically Ill Dogs With Systemic Inflammatory Response Syndrome.
Точное место: 2 Materials and Methods → 2.5 Outcome: определение исхода и лечение
Источник: Andreza Conti‐Patara, Linda G. Martin. Resting Cortisol Concentration as a Predictor of Illness Severity in Critically Ill Dogs With Systemic Inflammatory Response Syndrome. Journal of Veterinary Emergency and Critical Care, 2026. DOI: 10.1111/vec.70167
Условия использования: Creative Commons Attribution (CC BY 4.0): https://creativecommons.org/licenses/by/4.0/ Лицензия источника
Outcome was recorded as survival to hospital discharge or nonsurvival. All dogs that did not survive died of natural causes; dogs that were euthanized were excluded from the study. The treatment of each dog enrolled in the study was determined by its primary clinician.Связь с утверждением: подтверждает · полный текст · DOI 10.1111/vec.70167 · опубликован 25 сентября 2026
Resting Cortisol Concentration as a Predictor of Illness Severity in Critically Ill Dogs With Systemic Inflammatory Response Syndrome.
Точное место: 3 Results: абзац после Figure 1, число умерших и сравнение моделей прогноза смертности
Источник: Andreza Conti‐Patara, Linda G. Martin. Resting Cortisol Concentration as a Predictor of Illness Severity in Critically Ill Dogs With Systemic Inflammatory Response Syndrome. Journal of Veterinary Emergency and Critical Care, 2026. DOI: 10.1111/vec.70167
Условия использования: Creative Commons Attribution (CC BY 4.0): https://creativecommons.org/licenses/by/4.0/ Лицензия источника
Twelve of 30 dogs in the SIRS group and four of 25 dogs in the non‐SIRS group died. Resting serum cortisol concentrations tended to be higher in nonsurvivors (452.50 nmol/L; range: 162–1380 nmol/L [16.4 µg/dL; range: 5.8–50 µg/dL]) compared with survivors in the SIRS group (274.5 nmol/L; range: 73–1222 nmol/L [9.9 µg/dL; range: 2.6–44.2 µg/dL]); however, they were not significantly different (p = 0.1). In the non‐SIRS group, resting serum cortisol concentrations were the same in nonsurvivors (208.5 nmol/L; range: 121–494 [7.5 µg/dL, range: 4.3–17.9 µg/dL]) as in survivors (219 nmol/L; range: 74–861 [7.9 µg/dL; range: 2.6–31.2 µg/dL]; p = 0.9). The likelihood ratio tests were performed to assess the significance of the predictive outcomes of APPLE_full and APPLE_fast scores and resting serum cortisol concentration and to compare them with the model with only the group. There was no evidence that including APPLE_fast (p = 0.14) or resting serum cortisol concentration (p = 0.33) improves outcome prediction compared with a model with group factor alone. There was moderate evidence that including APPLE_full scores (p = 0.03) improves predictions of mortality.Связь с утверждением: подтверждает · полный текст · DOI 10.1111/vec.70167 · опубликован 25 сентября 2026
На чём основано · 1
В изученной выборке более высокой на 62,5 нмоль/л концентрации кортизола при поступлении соответствовал более высокий на 1 балл показатель тяжести состояния APPLE_full; 95%-й доверительный интервал оценки составлял 0,6–1,4 балла.
Граница вывода: Это статистическая связь с оценкой тяжести состояния, а не доказательство того, что кортизол вызывает ухудшение. Коэффициент регрессии не является порогом для решения о лечении или прогнозом для отдельной собаки. Наблюдение относится к измерению при поступлении и не описывает изменение показателей одной собаки во времени.
Resting Cortisol Concentration as a Predictor of Illness Severity in Critically Ill Dogs With Systemic Inflammatory Response Syndrome.
Точное место: ABSTRACT: Design, Setting, Animals, Interventions
Источник: Andreza Conti‐Patara, Linda G. Martin. Resting Cortisol Concentration as a Predictor of Illness Severity in Critically Ill Dogs With Systemic Inflammatory Response Syndrome. Journal of Veterinary Emergency and Critical Care, 2026. DOI: 10.1111/vec.70167
Условия использования: Creative Commons Attribution (CC BY 4.0): https://creativecommons.org/licenses/by/4.0/ Лицензия источника
Design
Prospective, observational study.
Setting
University teaching hospital.
Animals
Client‐owned dogs were enrolled into three different groups: SIRS (30 dogs), non‐SIRS (25), and healthy controls (19). Dogs with acute critical illness (<48 h) admitted to the ICU were enrolled and classified into SIRS and non‐SIRS groups. Healthy dogs were enrolled as controls. Resting serum cortisol concentrations were measured before treatment. APPLE full and fast scores were calculated at admission, with outcome recorded for each dog.
Interventions
None.Связь с утверждением: подтверждает · полный текст · DOI 10.1111/vec.70167 · опубликован 25 сентября 2026
Resting Cortisol Concentration as a Predictor of Illness Severity in Critically Ill Dogs With Systemic Inflammatory Response Syndrome.
Точное место: 3 Results: абзац непосредственно перед Figure 2, связь кортизола с APPLE_full
Источник: Andreza Conti‐Patara, Linda G. Martin. Resting Cortisol Concentration as a Predictor of Illness Severity in Critically Ill Dogs With Systemic Inflammatory Response Syndrome. Journal of Veterinary Emergency and Critical Care, 2026. DOI: 10.1111/vec.70167
Условия использования: Creative Commons Attribution (CC BY 4.0): https://creativecommons.org/licenses/by/4.0/ Лицензия источника
The APPLE_full scores increased by 1 (95% confidence interval [CI]: 0.6–1.4) for every increase of 62.5 nmol/L (2.2 µg/dL) in resting serum cortisol concentration (Figure 2).Связь с утверждением: подтверждает · полный текст · DOI 10.1111/vec.70167 · опубликован 25 сентября 2026
Resting Cortisol Concentration as a Predictor of Illness Severity in Critically Ill Dogs With Systemic Inflammatory Response Syndrome.
Точное место: 3 Results: абзац после Figure 1, предложение о составе регрессионной модели APPLE_full перед Table 1
Источник: Andreza Conti‐Patara, Linda G. Martin. Resting Cortisol Concentration as a Predictor of Illness Severity in Critically Ill Dogs With Systemic Inflammatory Response Syndrome. Journal of Veterinary Emergency and Critical Care, 2026. DOI: 10.1111/vec.70167
Условия использования: Creative Commons Attribution (CC BY 4.0): https://creativecommons.org/licenses/by/4.0/ Лицензия источника
A linear regression model was fit to relate the APPLE_full score to the three groups and resting serum cortisol concentration at the time of hospital admission (Table 1).Связь с утверждением: подтверждает · полный текст · DOI 10.1111/vec.70167 · опубликован 25 сентября 2026
На чём основано · 2
В этой выборке не получили статистических свидетельств того, что добавление кортизола при поступлении улучшает прогноз смертности по сравнению с моделью, учитывающей только группу (p = 0,33). Для добавления APPLE_full авторы сообщили умеренные статистические свидетельства улучшения прогноза (p = 0,03).
Граница вывода: Отсутствие статистических свидетельств улучшения не доказывает отсутствие прогностической связи в любой популяции. Результат относится к измерению при поступлении, выбранным группам и исходу до выписки; он не задаёт индивидуальную вероятность выживания.
Resting Cortisol Concentration as a Predictor of Illness Severity in Critically Ill Dogs With Systemic Inflammatory Response Syndrome.
Точное место: 2 Materials and Methods → 2.5 Outcome: определение исхода и лечение
Источник: Andreza Conti‐Patara, Linda G. Martin. Resting Cortisol Concentration as a Predictor of Illness Severity in Critically Ill Dogs With Systemic Inflammatory Response Syndrome. Journal of Veterinary Emergency and Critical Care, 2026. DOI: 10.1111/vec.70167
Условия использования: Creative Commons Attribution (CC BY 4.0): https://creativecommons.org/licenses/by/4.0/ Лицензия источника
Outcome was recorded as survival to hospital discharge or nonsurvival. All dogs that did not survive died of natural causes; dogs that were euthanized were excluded from the study. The treatment of each dog enrolled in the study was determined by its primary clinician.Связь с утверждением: подтверждает · полный текст · DOI 10.1111/vec.70167 · опубликован 25 сентября 2026
Resting Cortisol Concentration as a Predictor of Illness Severity in Critically Ill Dogs With Systemic Inflammatory Response Syndrome.
Точное место: 3 Results: абзац после Figure 1, число умерших и сравнение моделей прогноза смертности
Источник: Andreza Conti‐Patara, Linda G. Martin. Resting Cortisol Concentration as a Predictor of Illness Severity in Critically Ill Dogs With Systemic Inflammatory Response Syndrome. Journal of Veterinary Emergency and Critical Care, 2026. DOI: 10.1111/vec.70167
Условия использования: Creative Commons Attribution (CC BY 4.0): https://creativecommons.org/licenses/by/4.0/ Лицензия источника
Twelve of 30 dogs in the SIRS group and four of 25 dogs in the non‐SIRS group died. Resting serum cortisol concentrations tended to be higher in nonsurvivors (452.50 nmol/L; range: 162–1380 nmol/L [16.4 µg/dL; range: 5.8–50 µg/dL]) compared with survivors in the SIRS group (274.5 nmol/L; range: 73–1222 nmol/L [9.9 µg/dL; range: 2.6–44.2 µg/dL]); however, they were not significantly different (p = 0.1). In the non‐SIRS group, resting serum cortisol concentrations were the same in nonsurvivors (208.5 nmol/L; range: 121–494 [7.5 µg/dL, range: 4.3–17.9 µg/dL]) as in survivors (219 nmol/L; range: 74–861 [7.9 µg/dL; range: 2.6–31.2 µg/dL]; p = 0.9). The likelihood ratio tests were performed to assess the significance of the predictive outcomes of APPLE_full and APPLE_fast scores and resting serum cortisol concentration and to compare them with the model with only the group. There was no evidence that including APPLE_fast (p = 0.14) or resting serum cortisol concentration (p = 0.33) improves outcome prediction compared with a model with group factor alone. There was moderate evidence that including APPLE_full scores (p = 0.03) improves predictions of mortality.Связь с утверждением: подтверждает · полный текст · DOI 10.1111/vec.70167 · опубликован 25 сентября 2026
На чём основано · 3
До начала исследования расчёт предусматривал 150 собак, но включили 74. Пять собак, эвтаназированных вскоре после поступления по финансовым причинам, исключили. Авторы также отмечают неоднородность заболеваний, малые группы и отсутствие оценки кортизола в разные моменты госпитализации.
Граница вывода: Малые неоднородные группы ограничивают статистическую мощность и перенос результатов. Исключение эвтаназированных собак ограничивает применимость описанного исхода ко всем поступающим пациентам. Причинный эффект кортизола и преимущества изменения лечения не проверялись.
Resting Cortisol Concentration as a Predictor of Illness Severity in Critically Ill Dogs With Systemic Inflammatory Response Syndrome.
Точное место: ABSTRACT: Design, Setting, Animals, Interventions
Источник: Andreza Conti‐Patara, Linda G. Martin. Resting Cortisol Concentration as a Predictor of Illness Severity in Critically Ill Dogs With Systemic Inflammatory Response Syndrome. Journal of Veterinary Emergency and Critical Care, 2026. DOI: 10.1111/vec.70167
Условия использования: Creative Commons Attribution (CC BY 4.0): https://creativecommons.org/licenses/by/4.0/ Лицензия источника
Design
Prospective, observational study.
Setting
University teaching hospital.
Animals
Client‐owned dogs were enrolled into three different groups: SIRS (30 dogs), non‐SIRS (25), and healthy controls (19). Dogs with acute critical illness (<48 h) admitted to the ICU were enrolled and classified into SIRS and non‐SIRS groups. Healthy dogs were enrolled as controls. Resting serum cortisol concentrations were measured before treatment. APPLE full and fast scores were calculated at admission, with outcome recorded for each dog.
Interventions
None.Связь с утверждением: подтверждает · полный текст · DOI 10.1111/vec.70167 · опубликован 25 сентября 2026
Resting Cortisol Concentration as a Predictor of Illness Severity in Critically Ill Dogs With Systemic Inflammatory Response Syndrome.
Точное место: 2 Materials and Methods → 2.1 Animals: критерии включения, исключения и запланированная выборка
Источник: Andreza Conti‐Patara, Linda G. Martin. Resting Cortisol Concentration as a Predictor of Illness Severity in Critically Ill Dogs With Systemic Inflammatory Response Syndrome. Journal of Veterinary Emergency and Critical Care, 2026. DOI: 10.1111/vec.70167
Условия использования: Creative Commons Attribution (CC BY 4.0): https://creativecommons.org/licenses/by/4.0/ Лицензия источника
This was an observational, prospective study of dogs over 12 months of age with acute critical illnesses (illness present for <48 h) admitted to a university teaching hospital's small animal ICU from January of 2017 to October of 2018. The study was approved by the Institutional Animal Care and Use Committee, and all dogs were enrolled with written consent from their owners. Sixty client‐owned dogs were eligible for the study and were classified into SIRS and non‐SIRS groups based on the systemic inflammatory response variables of hypothermia (<38.1°C [100.6°F]) or hyperthermia (>39.2°C [102.6°F]), tachycardia (heart rate >120/min), tachypnea (respiratory rate >20/min), leukocytosis (>16 × 10^3 cells/µL), leukopenia (<6 × 10^3 cells/µL), or >3% bands on the WBC count. Based on the definition, patients with two or more criteria and an appropriate underlying condition are considered to have SIRS [12, 13]. To enhance the identification of critically ill patients, the current study considered patients with three or more SIRS variables to have SIRS [14]. Dogs that received exogenous corticosteroids, etomidate, or ketoconazole within the last 4 weeks, and dogs with known malignancies or diseases that involved the pituitary or adrenal glands, were excluded from the study in accordance with the exclusion criteria of a previous study [15]. Five dogs were euthanized shortly after ICU admission due to financial constraints and were excluded from the study, leaving 30 dogs in the SIRS group and 25 dogs in the non‐SIRS group. Additionally, 19 healthy client‐owned dogs that presented to the university teaching hospital's Community Practice service were enrolled as controls. These dogs were presented for elective periodontal treatment, and the relevant data were obtained on the preanesthetic evaluation. The same eligibility criteria were used for the control group as the SIRS and non‐SIRS groups. Dogs were classified as healthy based on history, physical examination, CBC, and serum biochemistry results. A power analysis was conducted before the study, indicating that 150 dogs should be included and distributed equally across the groups. However, due to an insufficient caseload and a specific inclusion criterion, a total of 74 dogs were ultimately enrolled.Связь с утверждением: подтверждает · полный текст · DOI 10.1111/vec.70167 · опубликован 25 сентября 2026
Resting Cortisol Concentration as a Predictor of Illness Severity in Critically Ill Dogs With Systemic Inflammatory Response Syndrome.
Точное место: 4 Discussion: абзац «The current study also showed», неоднородность заболеваний, малая выборка и отсутствие повторных измерений
Источник: Andreza Conti‐Patara, Linda G. Martin. Resting Cortisol Concentration as a Predictor of Illness Severity in Critically Ill Dogs With Systemic Inflammatory Response Syndrome. Journal of Veterinary Emergency and Critical Care, 2026. DOI: 10.1111/vec.70167
Условия использования: Creative Commons Attribution (CC BY 4.0): https://creativecommons.org/licenses/by/4.0/ Лицензия источника
The current study also showed that nonsurvivors often presented with numerically higher resting serum cortisol concentrations than survivors. However, no statistical difference was found between the two groups, which agrees with previous studies [7, 8, 18]. Resting serum cortisol concentrations did not predict mortality, likely due to the variability of disease processes and the small number of cases enrolled in each group. Serum cortisol concentration was a good predictor of outcome in dogs with parvoviral enteritis when resting serum cortisol was measured at 24 and 48 h of hospitalization [8] and at 72 h of hospitalization [7]. The current study did not evaluate resting serum cortisol concentrations at different time points; however, it may indicate that resting serum cortisol concentrations measured at times other than admission to the hospital may be more helpful in determining patient outcomes.Связь с утверждением: подтверждает · полный текст · DOI 10.1111/vec.70167 · опубликован 25 сентября 2026
Редакция Породотеки
Об этом материале
Кому и где применимо: Разбор относится к собакам с острым критическим заболеванием при поступлении в отделение интенсивной терапии и к здоровой группе сравнения. Он помогает понять различие между связью лабораторного показателя с тяжестью состояния и проверкой прогноза выживания; индивидуальный прогноз и выбор лечения из этой работы не следуют.
Проверка и история
- Опубликовано
- 22 октября 2026
- Проверено
- 22 октября 2026
- Финансирование
- Финансирование не оценивалось в этом разборе.
- Конфликт интересов
- Конфликты интересов не оценивались в этом разборе.
22 октября 2026 · Опубликована версия